Final Report Summary - PHD-OB-T2D (Study the role of oxygen sensors Prolyl Hydroxylase Domain (PHD) protein in obesity and type II diabetes)
The central aim of the proposed project was to elucidate the potential of prolyl hydroxylases domain (PHD) protein inhibition as a means to interfere with the development of obesity and type 2 diabetes (T2D). To this end we induced obesity via high fat diet (HFD) feeding in PHD-deficient mice and monitored whether PHD deficiency would have consequences on weight gain and obesity-associated medical complications such as insulin resistance (IR) and glucose intolerance (GI), which would ultimately lead to the development of T2D. We also aimed on determination of how loss of PHD function would alter pancreatic ß-cell physiology and whether alterations in glucose and lipid homeostasis would reveal a potentially beneficial effect to utilise PHD inhibition as a pharmaceutical intervention to treat obesity and T2D.
