Chagas' disease - Inhibitor discovery and optimization for Trypanosoma cruzi trans-sialidase

Informazioni relative al progetto

TRANSSIADRUG

ID dell’accordo di sovvenzione: 221740

Progetto chiuso

Data di avvio 1 Aprile 2008

Data di completamento 31 Agosto 2009

Finanziato da

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Costo totale € 157 288,66

Contributo UE € 157 288,66

Coordinato da

VIB VZW
Belgium

Obiettivo

This proposal focus on finding new potential lead compounds to inhibit the trans-sialidase of Trypanosoma cruzi, as a step towards finding a drug against Chagas’ disease. A new high through-put enzyme assay will be used to scan a large library of small molecules and in combination with in silico pharmacophoric modelling this is expected to provide new types of scaffolds as well as identifying important functionalities in the ligand. Based on the obtained information a set of ligands will be designed. These ligands will be synthesised and further evaluated through the enzyme assay, kinetic and thermodynamical studies as well as structural studies. In an iterative optimization, these tools will be combined to obtain future generations of inhibitory ligands.

Campo scientifico

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Parole chiave

• Biochemistry
• Computational chemistry
• Organic chemistry
• Pharmaceutical chemistry
• Structural chemistry
• Tropical medicine
• Trypanosoma cruzi
• inhibitor design

Programma(i)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Argomento(i)

• PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Invito a presentare proposte

FP7-PEOPLE-2007-2-1-IEF
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Meccanismo di finanziamento

MC-IEF - Intra-European Fellowships (IEF)

Coordinatore

VIB VZW

Contatto amministrativo

Wim Goemaere (Mr.)

• Contributo UE: € 157 288,66
• Indirizzo: SUZANNE TASSIERSTRAAT 1 ; 9052 ZWIJNAARDE - GENT ; Belgio
• Regione: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Gent
• Tipo di attività: Research Organisations
• Costo totale: Nessun dato