Final Report Summary - AUTOHEPARIN (Automated Synthesis of Heparin and Chondroitin Libraries for the Preparation of Diverse Carbohydrate Arrays)
Using the newly developed method, a large collection of oligosaccharides was prepared and attached to microarray surfaces, dendrimers and quantum dots. These molecular tools were employed to study the interaction of GAGs with growth factors, chemokines and other proteins. These fundamental insights resulted in a second funded ERC-POC grant to develop particular aspects of heparin arrays for use as diagnostics.