Construction of Well- defined Ubiquitin Conjugates

Projektinformationen

UB

ID Finanzhilfevereinbarung: 231024

Projekt abgeschlossen

Startdatum 15 Oktober 2008

Enddatum 14 Oktober 2011

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 45 000,00

EU-Beitrag € 45 000,00

Koordiniert durch

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

Ziel

Ubiquitination and deubiquitination of proteins has emerged as an important biological regulatory process. For any investigational and therapeutical purposes, well-defined ubiquitin(-like) conjugates are of prime importance and to date, these have mainly been constructed by enzyme based strategies. However, besides the general potential problems of enzymatic transformations (e.g. yield, isolation, expression), the promiscuous nature of ubiquitination severely limits their general applicability. Despite this and the growing evidence that structural organization of ubiquitin chains is more complicated and important than anticipated, the development of synthetic strategies towards well-defined Ub(ls) has received little attention. This proposal will present synthetic strategies which I believe hold great potential as general approaches towards well-defined ubiquitin conjugates. Chemical approaches and resulting reagents are not only desired for their analytical value but will also assist future developments of targeted therapeutics.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Schlüsselbegriffe

• ubiquitin

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• PEOPLE-2007-2-2.ERG - Marie Curie Action: "European Reintegration Grants"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-ERG-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-ERG - European Re-integration Grants (ERG)

Koordinator

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Kontakt Verwaltung

Henri Van Luenen (Dr.)

• EU-Beitrag: € 45 000,00
• Adresse: PLESMANLAAN 121 ; 1066 CX Amsterdam ; Niederlande
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten