Final Report Summary - ER_PARTNERS (Chromatin Mediators of Estrogen Receptor Biology)
We have delineated the role of estrogen receptor (ER) in breast cancer, by discovering how ER interacts with DNA, what factors are involved in determining where in the genome ER associates with and how this impinges on cancer cell growth. The findings have revealed novel therapeutic targets that are currently being explored and new opportunities for the treatment of drug resistant breast cancer patients. In parallel to the biological discoveries, the proposal resulted in the development of novel methods for better understanding of protein-DNA interactions and protein-protein interactions, methods that are applicable to many different research fields.