Cel
"The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data indicates that defects in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of SCF ubiquitin ligases contribute to oncogenesis. To achieve our goal we propose the following aims: Aim 1. To identify novel substrates for SCF ubiquitin ligases that have been shown to play roles in tumorigenesis. Aim 2. To identify ubiquitin ligases for tumor suppressor proteins and proto-oncoproteins that are targeted by the ubiquitin-proteasome pathway. Aim 3. To determine the contribution of defective SCF-mediated degradation to cancer."
Dziedzina nauki
Zaproszenie do składania wniosków
FP7-PEOPLE-2009-RG
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
MC-IRG - International Re-integration Grants (IRG)Koordynator
1011 JV AMSTERDAM
Niderlandy