Objectif The impact of reward and punishment on behavior is modulated by the neurotransmitters (chemicals that influence signal transfer between neurons) dopamine (DA) and serotonin (5-HT). This project tests a new model of the interplay between DA and 5-HT in motivational control of behavior, by studying the effects of DA and 5-HT increasing drugs on motivational learning and brain activation. Blood oxygen level dependent functional Magnetic Resonance Imaging (BOLD fMRI), a method often used to measure brain activity, is not adequate to assess drug-induced changes in brain activity. In this project new and promising fMRI techniques are used: arterial spin labeling (ASL) and calibrated BOLD fMRI. The results of this project are important for improving methodology in pharmacological fMRI research and may lead to improved treatment for psychiatric patients. The applicant will work for two years (outgoing phase) at the Center for Functional MRI, University of California, San Diego (UCSD), USA. Dr. T. Liu and his colleagues are world leading in the use and development of the abovementioned advanced fMRI techniques. Prof. M. Paulus of the Department of Psychiatry, UCSD, will collaborate on this project. During the return phase, the applicant will work at the Department of Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands, which houses experts in the field of psychopharmacology and toxicology of behavior. This collaboration results in a multidisciplinary research team of experts with excellent training records. The applicant has shown the potential to become a senior researcher. This fellowship will provide the applicant with goal-oriented training, the opportunity to develop complementary skills and to build an international network. The fellowship will make a major contribution to the applicant’s career and to the EU scientific excellence and competitiveness in the field of pharmacological neuroimaging. Champ scientifique medical and health sciencesclinical medicinepsychiatryengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingmedical and health sciencesbasic medicinetoxicology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2009-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur UNIVERSITEIT MAASTRICHT Contribution de l’UE € 237 911,80 Adresse MINDERBROEDERSBERG 4 6200 MD Maastricht Pays-Bas Voir sur la carte Région Zuid-Nederland Limburg (NL) Zuid-Limburg Type d’activité Higher or Secondary Education Establishments Contact administratif Liane Ligtenberg (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
