Obiettivo
This grant application is formulated to explore the biological role of the Cullin7 (CUL7) E3 ubiquitin ligase in insulin signaling and its implication for diabetes. My previous work led to the identification of insulin receptor substrate 1 (IRS-1) as the proteolytic target of the CUL7 E3 ligase and uncovered CUL7 as a novel regulator of insulin signaling. Based on these observations, I will employ experimental strategies as outlined in this proposal to delineate CUL7`s role for the cellular insulin response and its contribution to insulin resistance and type 2 diabetes.
Campo scientifico
Invito a presentare proposte
FP7-PEOPLE-2009-RG
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Meccanismo di finanziamento
MC-IRG - International Re-integration Grants (IRG)Coordinatore
80333 Muenchen
Germania