Cel
The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be implemented by a multidisciplinary team that combines some of Europe's leading academic TB researchers with two major pharmaceutical companies and four SMEs, all strongly committed to the discovery of anti-infective agents. MM4TB will use a tripartite screening strategy to discover new hits in libraries of natural products and synthetic compounds, while concentrating on both classical and innovative targets that have been pharmacologically validated. Whole cell screens will be conducted against Mycobacterium tuberculosis using in vitro and ex vivo models for active growth, latency and intracellular infection. Hits that are positive in two or more of these models will then be used for target identification using functional genomics technologies including whole genome sequencing and genetic complementation of resistant mutants, yeast three hybrid, click chemistry and proteomics. Targets thus selected will enter assay development, structure determination, fragment-based and rational drug design programs; functionally related targets will be found using metabolic pathway reconstruction. Innovative techniques, based on microfluidics and array platforms, will be used for hit ranking, determining rates of cidality and confirming mechanism of action. Medicinal chemistry will convert leads to molecules with drug-like properties for evaluation of efficacy in different animal models and late preclinical testing.
Dziedzina nauki
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesbasic medicinemedicinal chemistry
- medical and health sciencesclinical medicinepneumologytuberculosis
- natural sciencesbiological sciencesgeneticsgenomes
Zaproszenie do składania wniosków
FP7-HEALTH-2010-single-stage
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-IP - Large-scale integrating projectKoordynator
1015 Lausanne
Szwajcaria
Zobacz na mapie
Uczestnicy (26)
Zakończenie uczestnictwa
560024 BANGALORE
Zobacz na mapie
751 05 Uppsala
Zobacz na mapie
27100 Pavia
Zobacz na mapie
CB2 1TN Cambridge
Zobacz na mapie
Zakończenie uczestnictwa
E1 4NS London
Zobacz na mapie
75724 Paris
Zobacz na mapie
119071 MOSCOW
Zobacz na mapie
35122 Padova
Zobacz na mapie
814 99 Bratislava
Zobacz na mapie
8200 VESZPREM
Zobacz na mapie
NR4 7UH Norwich
Zobacz na mapie
560012 Bangalore
Zobacz na mapie
560066 BANGALORE
Zobacz na mapie
13100 Vercelli
Zobacz na mapie
94010 BURLINGAME CA
Zobacz na mapie
48940 Leioa
Zobacz na mapie
41126 Modena
Zobacz na mapie
50009 Zaragoza
Zobacz na mapie
8092 Zuerich
Zobacz na mapie
07749 JENA
Zobacz na mapie
94250 GENTILLY
Zobacz na mapie
7701 Rondebosch
Zobacz na mapie
Zakończenie uczestnictwa
1025 Saint Sulpice
Zobacz na mapie
75654 Paris
Zobacz na mapie
1015 Lausanne
Zobacz na mapie
65929 Frankfurt Am Main
Zobacz na mapie