Mid-Term Report Summary - POPRNASEQ (Population transcriptional genomics in humans using high throughput sequencing)
In the next phase of the project we will attempt to translate the knowledge we have obtained in further understanding the molecular and mechanistic relationship of gene expression and organismal complex traits. We are currently developing models to derive personalized transcriptomic profiles and we use them to integrate the joint effect of the genome and environment on the biology of the human body. We anticipate that this and similar approaches by others will eventually lead to the use of transcriptomics as a useful and standard clinical biomarker for the accurate prognosis and disease diagnosis.