Multifunctional Nanotechnology for selective detection and Treatment of cancer

Informations projet

MULTIFUN

N° de convention de subvention: 262943

Projet clôturé

Date de début 13 Juin 2011

Date de fin 12 Juin 2015

Financé au titre de

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Coût total € 13 150 553,64

Contribution de l’UE € 9 799 994,00

Coordonné par

ATOS SPAIN SA
Spain

Objectif

The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun magnetic nanoparticles will lead to potential medical applications such as contrast agents and magnetic heating inductors. Moreover, magnetic nanoparticles can be functionalised with ligands to increase their affinity towards cancer cells in order to facilitate diagnosis of tumours by MRI. Targeting peptides and antibodies will be employed, including antibodies against cancer stem cells leading to early cancer detection by MRI means. The same nanoparticles will be used simultaneously as functional nanocarriers and heating inductors in order to provide a combined therapeutic modality. The synergistic effects of drugs, peptides, small RNAs and heat will be evaluated to determine the effectiveness of different therapeutic combinations. Interestingly, the use of ligands will favour the specific application of the therapeutic modalities to cancer (stem) cells, increasing the effectiveness and reducing side effects. Thus, MultiFun multimodal therapeutic approach is designed to efficiently remove cancer cells, including cancer stem cells, from the tumour site. The toxicity of functionalised magnetic nanoparticles will be assessed in vitro and in vivo to warrant a safe use and shed some light on the risks. The distribution and activity evaluation of functionalised nanoparticles will be performed in human breast and pancreatic cancer xenograft models. The use of novel magnetic nanoparticles for biomedical applications provides opportunities for new instrumentation: 1) detection and quantification of magnetic nanoparticles in blood, urine and tissues, and 2) magnetic heating induction for raising cell temperature.

Champ scientifique

• natural sciences › biological sciences › biochemistry › biomolecules
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › biological sciences › genetics › RNA
• engineering and technology › nanotechnology › nano-materials
• medical and health sciences › clinical medicine › oncology › pancreatic cancer

Programme(s)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Thème(s)

• NMP-2010-4.0-1 - Development of nanotechnology-based systems for detection, diagnosis and therapy for cancer

Appel à propositions

FP7-NMP-2010-LARGE-4
Voir d’autres projets de cet appel

Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

ATOS SPAIN SA

Contact administratif

Blanca Jordan (Ms.)

• Contribution de l’UE: € 810 390,00
• Adresse: CALLE DE ALBARRACIN 25 ; 28037 Madrid ; Espagne
• Région: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coût total: Aucune donnée

Participants (16)

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III

Participation terminée

Espagne

Contact administratif

Laura Bertolini (Ms.)

• Contribution de l’UE: € 445 919,52
• Adresse: C MELCHOR FERNANDEZ ALMAGRO 3 ; 28029 Madrid
• Région: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Type d’activité: Research Organisations
• Coût total: Aucune donnée

UNIVERSITE PARIS XII VAL DE MARNE

France

Contact administratif

José Courty (Dr.)

• Contribution de l’UE: € 321 050,00
• Adresse: AVENUE DU GENERAL DE GAULLE 61 ; 94010 Creteil
• Région: Ile-de-France › Ile-de-France › Val-de-Marne
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Espagne

Contact administratif

Eusebio Jimenez Arroyo (Mr.)

• Contribution de l’UE: € 1 213 573,00
• Adresse: CALLE SERRANO 117 ; 28006 Madrid
• Région: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Type d’activité: Research Organisations
• Coût total: Aucune donnée

FYZIKALNI USTAV AV CR V.V.I

Tchéquie

Contact administratif

Jana Poltierova Vejpravova (Dr.)

• Contribution de l’UE: € 449 999,00
• Adresse: NA SLOVANCE 1999/2 ; 182 21 Praha 8
• Région: Česko › Praha › Hlavní město Praha
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

FUNDACION IMDEA NANOCIENCIA

Espagne

Contact administratif

María Jesús Villa Hormaeche (Dr.)

• Contribution de l’UE: € 875 680,00
• Adresse: CALLE FARADAY 9 CIUDAD UNIVERSITARIA DE CANTOBLANCO ; 28049 Madrid
• Région: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Type d’activité: Research Organisations
• Coût total: Aucune donnée

INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE

France

Contact administratif

Marc Respaud (Prof.)

• Contribution de l’UE: € 518 020,00
• Adresse: AVENUE DE RANGUEIL 135 ; 31077 TOULOUSE CEDEX 4
• Région: Occitanie › Midi-Pyrénées › Haute-Garonne
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

KING'S COLLEGE LONDON

Royaume-Uni

Contact administratif

Paul Labbett (Mr.)

• Contribution de l’UE: € 571 937,00
• Adresse: STRAND ; WC2R 2LS London
• Région: London › Inner London — West › Westminster
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

LIQUIDS RESEARCH LTD

Royaume-Uni

Contact administratif

Vijay Patel (Dr.)

• Contribution de l’UE: € 402 823,00
• Adresse: DEINIOL ROAD UNIT 3B MENTEC ; LL57 2UP BANGOR
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coût total: Aucune donnée

SOLUCIONES NANOTCNOLOGICAS SL

Participation terminée

Espagne

Contact administratif

Sebastian Gargallo (Mr.)

• Contribution de l’UE: Aucune donnée
• Adresse: POLIGONO INDUSTRIAL EL ZAFRANAR ; 50550 ZARAGOZA
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coût total: Aucune donnée

PEPRIC NV

Belgique

Contact administratif

Stephanie Teughels (Dr.)

• Contribution de l’UE: € 496 148,00
• Adresse: KAPELDREEF 75 ; 3001 Leuven
• Région: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coût total: Aucune donnée

PHARMA MAR SA

Espagne

Contact administratif

Pilar Calvo (Dr.)

• Contribution de l’UE: € 219 912,00
• Adresse: AVDA DE LOS REYES 1 POLIGONO INDUSTRIAL LA MINA COLMENAR VIEJO ; 28770 Madrid
• Région: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coût total: Aucune donnée

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Irlande

Contact administratif

Deirdre Savage (Ms.)

• Contribution de l’UE: € 1 059 807,00
• Adresse: COLLEGE GREEN TRINITY COLLEGE ; D02 CX56 DUBLIN 2
• Région: Ireland › Eastern and Midland › Dublin
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Irlande

Contact administratif

Farouk Markos (Dr.)

• Contribution de l’UE: € 298 972,00
• Adresse: WESTERN ROAD ; T12 YN60 Cork
• Région: Ireland › Southern › South-East
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

UNIVERSITATSKLINIKUM JENA

Allemagne

Contact administratif

Ingrid Hilger (Prof.)

• Contribution de l’UE: € 1 003 160,00
• Adresse: KASTANIENSTR.1 ; 07747 Jena
• Région: Thüringen › Thüringen › Jena, Kreisfreie Stadt
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

THE UNIVERSITY OF MANCHESTER

Royaume-Uni

Contact administratif

Liz Fay (Ms.)

• Contribution de l’UE: € 838 107,00
• Adresse: OXFORD ROAD ; M13 9PL Manchester
• Région: North West (England) › Greater Manchester › Manchester
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée

QUEEN MARY UNIVERSITY OF LONDON

Royaume-Uni

Contact administratif

Vicky Byers (Ms.)

• Contribution de l’UE: € 274 496,48
• Adresse: 327 MILE END ROAD ; E1 4NS London
• Région: London › Inner London — East › Tower Hamlets
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée