Objectif In Systems Chemical Biology research small drug-like molecules are employed to analyze the construction, wiring and spatiotemporal regulation of protein networks in dynamic biological systems. They act fast, reversibly, conditional, do not alter network architecture and need to be biologically relevant, a property particularly given for the scaffolds of natural product classes chosen in evolution to interact with proteins and to modulate dynamic biological systems.In the research project novel cheminformatic methods will be developed to analyse all known natural products and additional biologically relevant compound classes and to identify natural product fragments in order to guide the synthesis of natural product-inspired compound collections each of ca. 500-1000 members with high scaffold diversity (in particular indoles, spirooxidoles, tetrahydropyrans, iridoids, lactones, hybrid natural products). The synthesis will include the development of novel organic synthesis methodology with a special emphasis on enantioselective catalysis and multi-step Domino sequences. The compound collection will be screened in unbiased phenotypic assays monitoring mitosis and dynamic signal transduction pathways. The patterns of cellular targets of hit compounds will be identified and validated by means of chemical proteomics, biochemistry, biophysics and cell biology investigations, and novel chemical probes for the study of dynamic biological processes and systems will be devised.Systems Chemical Biology research will have a major impact on basic science by opening up unprecedented opportunities for the study of dynamic biological systems enabling breakthrough discoveries, and it will create a novel systematic means to identify drug candidates that target multiple proteins. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencescell biologynatural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiophysics Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-LS2 - ERC Advanced Grant - Genetics, Genomics, Bioinformatics and Systems Biology Appel à propositions ERC-2010-AdG_20100317 Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Contribution de l’UE € 2 476 400,00 Adresse HOFGARTENSTRASSE 8 80539 Munchen Allemagne Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Research Organisations Chercheur principal Herbert Waldmann (Prof.) Contact administratif Barbara Dobruchowski (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Allemagne Contribution de l’UE € 2 476 400,00 Adresse HOFGARTENSTRASSE 8 80539 Munchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Research Organisations Chercheur principal Herbert Waldmann (Prof.) Contact administratif Barbara Dobruchowski (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
