Obiettivo Traffic-related air pollution is an important environmental problem that may affect neurodevelopment. Ultrafine particles (UFP) translocate to the brains of experimental animals resulting in local proinflammatory overexpression. As the basic elements for thinking are acquired by developing brains during infancy and childhood, susceptibility may be elevated in early life.We postulate that traffic-related air pollution (particularly UFPs and metals/hydrocarbons content) impairs neurodevelopment in part via effects on frontal lobe maturation, likely increasing attention-deficit/hyperactivity disorder (ADHD). BREATHE objectives are to develop valid methods to measure children's personal UFP exposure and to develop valid neuroimaging methods to assess correlations between neurobehavior, neurostructural alterations and particle deposition in order to reveal how traffic pollution affects children¿s exposure to key contaminants and brain development, and identify susceptible subgroups.We have conducted general population birth cohort studies providing preliminary evidence of residential air pollution effects on prenatal growth and mental development.We aim to demonstrate short and long-term effects on neurodevelopment using innovative epidemiological methods interfaced with environmental chemistry and neuroimaging following 4000 children from 40 schools with contrasting high/low traffic exposure in six linked components involving: repeated psychometric tests, UFP exposure assessment using personal, school and home measurements, gene-environment interactions on inflammation, detoxification pathways and ADHD genome-wide-associated genes, neuroimaging (magnetic resonance imaging/spectroscopy) in ADHD/non-ADHD children, integrative causal modeling using mathematics, and replication in 2900 children with neurodevelopment followed from pregnancy.We believe the expected results will have worldwide global planning and policy implications. Campo scientifico natural scienceschemical sciencesorganic chemistryhydrocarbonsengineering and technologyenvironmental engineeringair pollution engineeringnatural sciencesearth and related environmental sciencesenvironmental sciencespollutionnatural sciencesmathematicsnatural sciencesphysical sciencesopticsspectroscopy Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Invito a presentare proposte ERC-2010-AdG_20100317 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Contributo UE Nessun dato Indirizzo C ROSSELLO 132 PLANTA 05 08036 Barcelona Spagna Mostra sulla mappa Regione Este Cataluña Barcelona Tipo di attività Research Organisations Ricercatore principale Jordi Sunyer Deu (Prof.) Contatto amministrativo Joana Porcel (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Spagna Contributo UE Nessun dato Indirizzo C ROSSELLO 132 PLANTA 05 08036 Barcelona Mostra sulla mappa Regione Este Cataluña Barcelona Tipo di attività Research Organisations Ricercatore principale Jordi Sunyer Deu (Prof.) Contatto amministrativo Joana Porcel (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL Partecipazione conclusa Spagna Contributo UE € 2 072 030,00 Indirizzo Calle Doctor Aiguader 88 08003 BARCELONA Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Joana Porcel (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE € 187 200,00 Indirizzo CALLE SERRANO 117 28006 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Research Organisations Contatto amministrativo Eusebio Jimenez Arroyo (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato NEUROVOXEL SLP Spagna Contributo UE € 240 000,00 Indirizzo C/MONTSENY 19 - P2 08550 BARELONA Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Jesús Pujol (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato