Objectif It is now >10 years since the remarkable discovery that photoreception in the mammalian retina occurs outside of rod and cone cells. In that time we have learnt a great deal about the melanopsin expressing retinal ganglion cells (mRGCs) that provide this non-rod non-cone photoreception, and about their extensive contribution to sub-conscious light responses. However, one idea that has persisted is that these mRGCs play little if any role in visual perception. Exciting new data challenge that view. Thus, we have recently described an extraordinarily extensive mRGC input to the primary visual pathway. This provides ~40% of neurones in the mouse visual thalamus with melanopsin signals, superimposed upon more conventional visual information. The discovery of this unexpected sensory input to the mammalian visual system raises several important questions: What does it contribute to vision? How is the melanopsin signal brought to the thalamus and how is it propagated/processed through higher visual centres? Does melanopsin help people with retinal degeneration (in which mRGCs long outlive rods and cones) to see? Could optimising melanopsin vision offer a new strategy for improving vision in these people? We propose addressing these questions by using state-of-the-art neurophysiological and anatomical techniques in mice. Our overarching objectives are Objective 1: What does melanopsin contribute to vision? Objective 2: How is melanopsin vision impacted by retinal degeneration? Champ scientifique medical and health sciencesclinical medicineophthalmology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Appel à propositions ERC-2010-AdG_20100317 Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil THE UNIVERSITY OF MANCHESTER Contribution de l’UE € 2 499 636,00 Adresse OXFORD ROAD M13 9PL Manchester Royaume-Uni Voir sur la carte Région North West (England) Greater Manchester Manchester Type d’activité Higher or Secondary Education Establishments Chercheur principal Robert James Lucas (Prof.) Contact administratif Liz Fay (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY OF MANCHESTER Royaume-Uni Contribution de l’UE € 2 499 636,00 Adresse OXFORD ROAD M13 9PL Manchester Voir sur la carte Région North West (England) Greater Manchester Manchester Type d’activité Higher or Secondary Education Establishments Chercheur principal Robert James Lucas (Prof.) Contact administratif Liz Fay (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée