Computational study of the interaction between inhaled carbon nanoparticles and lung membranes

Projektinformationen

PLUM

ID Finanzhilfevereinbarung: 274821

Projekt abgebrochen

Startdatum 1 Juni 2011

Enddatum 31 Mai 2013

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 179 548,00

EU-Beitrag € 179 548,00

Koordiniert durch

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Ziel

"We hereby propose a study on the physical and biological basis of the interaction between inhaled carbon nanoparticles and lung membranes, by computational approach.

The past decades have seen hundreds of new applications of nanomaterials developed and patented. At the same time, the scientific community is encouraged to devote research efforts to assess the safety of nanotechnology products. The PLUM project focuses on the effects of inhaled carbon nanoparticles and carbon nanotubes. Inhalation of carbon nanoparticles, one of the major byproducts of combustion processes, may happen to all of us, when stuck in a traffic jam in our city. Specialized workers may be exposed, as well, during the production or dispersion of carbon nanoparticles and nanofibers, or when cutting or re-processing a composite material containing carbon nanotubes. During inhalation, the first barrier which nanoparticles bump into is the lung membrane, which coats the inner surface of alveoli. Lung membranes are our first line of defense against foreign substances attempting to enter our organism via air and they are crucial for breathing, regulating gas exchange at the water-air interface of the alveoli.
Understanding the mechanisms of nanoparticle interaction with lung membranes is a fundamental step for the assessment of NPs hazardousness. PLUM will pursue this objective by studying this interaction at molecular level, addressing at the same time physical and biological effects by computational techniques. We will consider both carbon nanoparticles and nanotubes, and we will investigate their influence on the membrane properties and the mechanism of permeation through lung membranes. These effects will be studied as a function of physical properties (e.g. size, shape) and chemical features (coating and functionalization). PLUM will mainly rely on Molecular Dynamics simulations, and it will devote important efforts to the development of new models at all-atom and coarse-grained level."

Wissenschaftliches Gebiet

• engineering and technology › materials engineering › composites
• engineering and technology › materials engineering › coating and films
• engineering and technology › nanotechnology › nano-materials

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2010-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Kontakt Verwaltung

Patrick Widart (Dr.)

• EU-Beitrag: € 179 548,00
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten