The nuclear pore connection: adaptor complexes bridging genome regulation and nuclear transport

Projektinformationen

NPC GENEXPRESS

ID Finanzhilfevereinbarung: 281354

Abgeschlossenes Projekt

Startdatum 1 November 2011

Enddatum 31 Oktober 2016

Finanziert unter

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 1 481 556,00

EU-Beitrag € 1 481 556,00

Koordiniert durch

MEDIZINISCHE UNIVERSITAET WIEN
Austria

Ziel

Nuclear pore complexes (NPCs) form macromolecular assemblies in the nuclear envelope and mediate bidirectional cargo movement between the nucleus and cytoplasm. Recent evidence suggests that NPCs are not merely transport channels but act as gene regulators. Studies in yeast demonstrate that inducible genes can reposition from the nuclear interior to the nuclear periphery upon activation. At the periphery activated genes engage in physical contacts with nuclear pores. Targeting and tethering of genes to nuclear pores involves multifunctional adaptor complexes, which are thought to couple chromatin modification, transcription and mRNA export. Knowledge of the structure, dynamics and evolution of these adaptor complexes is key to understanding how NPCs control nuclear gene positioning and gene expression. I propose to systematically dissect the architecture and function of NPC-associated adaptor complexes. Our studies will be a unique combination of biochemical and structural approaches in three different model organisms. I anticipate, that this line of research will create a powerful basis to address a number of key questions in the field.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › genetics › genomes

Programm/Programme

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• ERC-SG-LS1 - ERC Starting Grant - Molecular and Structural Biology and Biochemistry

Aufforderung zur Vorschlagseinreichung

ERC-2011-StG_20101109
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERC-SG - ERC Starting Grant

Gastgebende Einrichtung

MEDIZINISCHE UNIVERSITAET WIEN

Hauptforscher

Alwin Köhler (Dr.)

Kontakt Verwaltung

Alwin Köhler (Dr.)

• EU-Beitrag: € 1 481 556,00
• Adresse: SPITALGASSE 23 ; 1090 Wien ; Österreich
• Region: Ostösterreich › Wien › Wien
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

Begünstigte (1)

MEDIZINISCHE UNIVERSITAET WIEN

Österreich

Hauptforscher

Alwin Köhler (Dr.)

Kontakt Verwaltung

Alwin Köhler (Dr.)

• EU-Beitrag: € 1 481 556,00
• Adresse: SPITALGASSE 23 ; 1090 Wien
• Region: Ostösterreich › Wien › Wien
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten