Studying the Mechanisms of Enhanced Pathogenesis<br/>in Polymicrobial Respiratory Co-Infection

Projektinformationen

ReCoIn

ID Finanzhilfevereinbarung: 299674

Abgeschlossenes Projekt

Startdatum 7 März 2012

Enddatum 6 März 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 209 033,40

EU-Beitrag € 209 033,40

Koordiniert durch

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

Ziel

Illness caused by respiratory infection with Influenza viruses represents a vast healthcare and economic burden in the modern world. It is well established that respiratory viral infections are often complicated by secondary bacterial infections, however co-infection often causes a much more severe disease than either microorganism would individually. The mechanisms behind this synergy are not fully understood, however adhesion; the first step in bacterial colonisation, has been shown to be enhanced in virus-infected cells. We hypothesise that early events following Influenza infection of lung epithelium promote bacterial adhesion by regulating primary receptor trafficking and may offer new targets for anti-bacterial intervention.

The aims of this project are to dynamically characterise the adhesion of individual bacteria to airway epithelial cells with high-temporal and spatial resolution and to study the effects of Influenza A co-infection on this phenomenon. We will develop new protocols to track bacteria in three dimensions in order to study individual adhesion events and will calculate diffusion modes during and after bacterial contact with the host cells. These studies will provide novel insights into the processes underlying bacterial adhesion and will explore the mechanism of viral-bacterial synergy to discover new targets for the prevention and treatment of serious respiratory infections.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases › RNA viruses › influenza

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2011-IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

THE UNIVERSITY OF BIRMINGHAM

Kontakt Verwaltung

May Chung (Ms.)

• EU-Beitrag: € 209 033,40
• Adresse: Edgbaston ; B15 2TT Birmingham ; Vereinigtes Königreich
• Region: West Midlands (England) › West Midlands › Birmingham
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten