Objectif Proteins need to be correctly folded to carry out their biological function. Failure to fold leads to aberrant protein conformations that have an increased tendency to aggregate and have deleterious effect on cell viability. Eukaryotes have developed a sophisticated protein quality control (QC) system that protects cells from misfolded or incompletely synthesized polypeptides that would otherwise interfere with normal cellular functions or even induce cellular death. The QC system may promote refolding of these non-native proteins by molecular chaperones, enhance their degradation by the ubiquitin-proteasome system or autophagy, or terminally sequester these misfolded proteins in inclusion bodies called IPODs. Impairment of the activity of this QC system, for instance due to ageing or disease, is thought to underlie the growing number of age-related aggregation disorders, such as Parkinson, Alzheimer and Huntington disease, all of which are characterized by accumulation of misfolded aggregated proteins. At present, it remains largely elusive how the quality control machinery recognizes misfolded proteins, and how the triage decision is implemented: i.e. why certain misfolded proteins are refolded whereas others are targeted for degradation or sequestered in cellular inclusions. The goal of this project is therefore to identify the played of the QC machinery and define how the interplay between molecular chaperones and degradation pathways maintain cellar protein homeostasis. The proposed work will build on the large body of work of the host laboratories and will combine systems approaches with cell biology and biochemistry to address these important questions. Champ scientifique medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2011-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2011-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur UNIVERSITEIT UTRECHT Contribution de l’UE € 263 660,70 Adresse HEIDELBERGLAAN 8 3584 CS Utrecht Pays-Bas Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Contact administratif Ineke Braakman (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
