Objective The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presentation, in co-morbidities and in microbiological aetiology. Thus, there is an urgent need for novel diagnostic and therapeutic strategies in order to improve outcome of NSTIs. To achieve this, a comprehensive and integrated knowledge of diagnostic features, causative microbial agent, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) is required. INFECT is designed to obtain such insights through an integrated systems biology approach in patients and different clinically relevant experimental models.Specific objectives of INFECT are to:1. Unravel specific mechanisms underlying diseases signatures though a bottom-up systems approach applied to clinically relevant experimental settings2. Apply a top-down systems biology approach to NSTI patient samples to pin-point key host and pathogen factors involved in the onset and development of infection3. Identify and quantify disease signatures and underlying networks that contribute to disease outcome4. Exploit identified disease traits for the innovation of optimized diagnostic tools5. Translate the advanced knowledge generated into evidence-based guidelines for classification and management, and novel therapeutic strategiesWe have gathered a team of multidisciplinary researchers, clinicians, SMEs and a patient organization, each with a unique expertise, technical platform and/or model systems that together provide the means to successfully conduct the multifaceted research proposed and efficiently disseminate/exploit the knowledge obtained. Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.1.2-2 - Systems medicine: Applying systems biology approaches for understanding multifactorial human diseases and their co-morbidities Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator KAROLINSKA INSTITUTET EU contribution € 2 110 979,00 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Klas Karlsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all REGION HOVEDSTADEN Denmark EU contribution € 1 607 774,00 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Jacob Trier Moeller (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data REGION STOCKHOLM Sweden EU contribution € 385 094,75 Address HANTVERKARGATAN 45 104 22 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Lars Eriksson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BLEKINGE LANS LANDSTING Sweden EU contribution € 45 197,00 Address Friskvägen Byggn 2 37185 Karlskrona See on map Region Södra Sverige Sydsverige Blekinge län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ylva Karlsson (Dr.) Links Contact the organisation Opens in new window Total cost No data VÄSTRA GÖTALANDSREGIONEN Sweden EU contribution € 435 000,00 Address REGIONENS HUS 462 80 Vanersborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Sven-Erik Ricksten (Prof.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITETET I BERGEN Norway EU contribution € 896 513,00 Address MUSEPLASSEN 1 5020 Bergen See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Administrative Contact Liv-Grethe Gudmundsen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University of Cincinnati Participation ended United States EU contribution € 93 736,75 Address Cincinnati,Ohio 45221-0222 Cincinnati See on map Activity type Higher or Secondary Education Establishments Administrative Contact Mary Ucci (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Germany EU contribution € 1 752 400,00 Address INHOFFENSTRASSE 7 38124 Braunschweig See on map Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Michael Straetz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WAGENINGEN UNIVERSITY Netherlands EU contribution € 1 324 548,00 Address DROEVENDAALSESTEEG 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Higher or Secondary Education Establishments Administrative Contact Tom Bessems (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE LYON 1 CLAUDE BERNARD France EU contribution € 356 799,00 Address BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Javier Olaiz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIFEGLIMMER GMBH Germany EU contribution € 610 354,00 Address MARKELSTRASSE 38 12163 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Susanne Hollmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ANAGNOSTICS BIOANALYSIS GMBH Participation ended Austria EU contribution € 276 879,88 Address WESTBAHNSTRASSE 55 4300 ST VALENTIN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Chrsitoph Reschreiter (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MARSDEN DOREEN United Kingdom EU contribution € 47 445,00 Address MOOR HEY FARM KNOWLE GREEN PR2 2XE PRESTON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Doreen Marsden (Mrs.) Links Contact the organisation Opens in new window Total cost No data TEL AVIV UNIVERSITY Israel EU contribution € 332 000,00 Address RAMAT AVIV 69978 Tel Aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF NORTH DAKOTA United States EU contribution € 1 333 730,25 Address CENTENNIAL DRIVE 264 STOP 8356 TWAMLEY HALL ROOM 115 58202 8356 GRAND FORKS ND See on map Activity type Higher or Secondary Education Establishments Administrative Contact Diane Hillebrand (Ms.) Links Contact the organisation Opens in new window Total cost No data CUBE DX GMBH Austria EU contribution € 305 140,37 Address WESTBAHNSTRASSE 55 4300 ST VALENTIN See on map Region Ostösterreich Niederösterreich Mostviertel-Eisenwurzen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christoph Reschreiter (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data