Objectif "The focus of this research project will be on halogen bonding, namely any noncovalent interactions involving halogen atoms as electrophilic species (electron density acceptor sites, Lewis acids, halogen bonding-donors). In particular, the overall goal of the project will be to fully elucidate the capabilities and properties of halogen atoms as recognition “sticky” sites in the context of biomolecules.The general objective of this research project will be achieved through the application of a multi-dimensional approach to the understanding of the intermolecular interactions involving halogenated molecules in chemistry and biology. The programme of work will centre around three closely integrated and synergistic strands. The common theme is to exploit halogen bonding for the design of “smart” peptides and foldamers (Strand 1), the obtainment of complexes of polyhalogenated organic pollutants with serum proteins (Strand 2), and to assemble biomimetic sensors for polyhalogenated organic pollutants (Strand 3).For the first time a multidisciplinary team composed by synthetic chemists, small molecule crystallographers, biologists, physicists, and protein crystallographers will join forces around the fundamental issues of: a) contributing to the establishment of the nature and properties of halogen bonding in ligand/biomolecule systems; b) improving our understanding of long-distance intermolecular interactions and their role on the energy profiles of biochemical transformations; c) facilitating preparation of more rationally designed new halogenated drugs; d) allowing for the mechanistic understanding of reactivity of halogen-containing molecules for the development of efficient and ""green"" synthetic and bioremediation methods.The overall aim of this project is, therefore, to enlighten to the scientific community the potential that halogen bonding has to become a very powerful tool in the manipulation of molecular recognition phenomena in chemistry and biology." Champ scientifique engineering and technologyenvironmental biotechnologybioremediationnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsnatural scienceschemical sciencesinorganic chemistryhalogens Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Appel à propositions ERC-2012-StG_20111012 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil POLITECNICO DI MILANO Contribution de l’UE € 1 129 000,00 Adresse PIAZZA LEONARDO DA VINCI 32 20133 Milano Italie Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Higher or Secondary Education Establishments Chercheur principal Pierangelo Metrangolo (Prof.) Contact administratif Samuele Paolo Bordogna (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire POLITECNICO DI MILANO Italie Contribution de l’UE € 1 129 000,00 Adresse PIAZZA LEONARDO DA VINCI 32 20133 Milano Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Higher or Secondary Education Establishments Chercheur principal Pierangelo Metrangolo (Prof.) Contact administratif Samuele Paolo Bordogna (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée TEKNOLOGIAN TUTKIMUSKESKUS VTT Participation terminée Finlande Contribution de l’UE € 40 032,00 Adresse TEKNIIKANTIE 4 A 02044 VTT ESPOO Voir sur la carte Type d’activité Research Organisations Contact administratif Sinikka Soirinsuo (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée AALTO KORKEAKOULUSAATIO SR Finlande Contribution de l’UE € 223 968,00 Adresse OTAKAARI 1 02150 Espoo Voir sur la carte Région Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Type d’activité Higher or Secondary Education Establishments Contact administratif Olli Ikkala (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
