Objectif Psychotic disorders are amongst the most severe mental disorders. However, current treatments have failed to reduce disability or change the prospects for recovery for patients with a psychotic disorder. In this project, I will investigate an entirely novel therapy, targeting the core vulnerability profile of altered person-environment interactions underlying psychosis, specifically increased stress-reactivity and reduced motivated and goal-directed behaviour. My colleagues and I have developed a digital apparatus, the ‘PsyMate’, allowing real-time interventions for patients with severe mental illness. In this project, the PsyMate will be used to (1)reduce psychotic and emotional reactivity to stress with “detachment and acceptance” exercises in real life situations, and (2)improve motivated and goal-directed behaviour with real-time behavioural activation therapy. In a randomized controlled trial, I will investigate whether this self-management therapy, conducted outside the office in the patient’s real life, is capable of reducing psychotic reactivity to stress and of improving motivated behaviour in participants with an at-risk mental state for psychosis.In order to understand the impact of this intervention in terms of brain plasticity and prediction of response, I will use an experimental medicine approach to investigate the neural effects of the intervention. I will focus particularly on prefrontal dopamine-reactivity as the brain mechanism mediating altered person-environment interactions. In the current study, I will examine prefrontal dopamine reactivity towards positive as well as stressful negative events as the biological process mediating underlying motivated behaviour and environmental reactivity. Furthermore, I will investigate whether a self-management therapy specifically focused at aberrant person-environment interactions alters brain plasticity at the level of prefrontal dopaminergic neurotransmission in persons at risk for psychosis. Champ scientifique medical and health sciencesclinical medicinepsychiatry Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Appel à propositions ERC-2012-StG_20111109 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil KATHOLIEKE UNIVERSITEIT LEUVEN Contribution de l’UE € 724 682,69 Adresse OUDE MARKT 13 3000 Leuven Belgique Voir sur la carte Région Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Type d’activité Higher or Secondary Education Establishments Contact administratif Stijn Delaure (Dr.) Chercheur principal Inez Yvonne Ronald Germeys (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire KATHOLIEKE UNIVERSITEIT LEUVEN Belgique Contribution de l’UE € 724 682,69 Adresse OUDE MARKT 13 3000 Leuven Voir sur la carte Région Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Type d’activité Higher or Secondary Education Establishments Contact administratif Stijn Delaure (Dr.) Chercheur principal Inez Yvonne Ronald Germeys (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAETSKLINIKUM AACHEN Participation terminée Allemagne Contribution de l’UE € 161 686,18 Adresse Pauwelsstrasse 30 52074 Aachen Voir sur la carte Région Nordrhein-Westfalen Köln Städteregion Aachen Type d’activité Higher or Secondary Education Establishments Contact administratif Volker Legewie (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITEIT MAASTRICHT Participation terminée Pays-Bas Contribution de l’UE € 612 527,13 Adresse MINDERBROEDERSBERG 4 6200 MD Maastricht Voir sur la carte Région Zuid-Nederland Limburg (NL) Zuid-Limburg Type d’activité Higher or Secondary Education Establishments Contact administratif Laurent Louwies (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
