Obiettivo Schistosomiasis is an important parasitic disease in the developing world and is largely chronic in nature. Helminth infections, such as Schistosoma sp., often cause down-regulation of the adaptive immune response possibly through long-term, or repeated stimulation of the innate immune system following binding of parasite molecules to a limited number of innate receptors (e.g. Toll-like receptors). This aspect of the immune system represents a novel route to exploit in future control programs.Therefore, our proposal has four objectives.1. We will investigate differences in the innate immune response, specifically of innate receptors in groups of individuals with different histories of infection and extent of pathology, which will be further dissected in models of infection.2 Glycan structures on molecules released by schistosomes are important candidate ligands of host innate receptors and so will be characterised, isolated and synthesised.3 Isolated molecules will be tested using human in vitro assays and in vivo model systems, to identify those molecules with the greatest capacity to enhance or regulate immune responsiveness. These molecules bear promise as potential adjuvants in drug and vaccine control programmes, or as therapeutics to control pathology.4 Finally, Geographical Information Systems will be applied to link features of the innate immune response to the history of exposure, and expression of pathology.This framework will facilitate the implementation of drug and vaccine control programmes to those most at risk. The proposal is based upon a multidisciplinary and integrated consortium bringing together field based researchers (epidemiologists, health care workers), statisticians, and basic scientists (immunologists, biochemists) from 3 African and 3 European countries. Together, the partners will deliver an innovative project that will identify novel strategies that will aid the control of schistosomiasis. Campo scientifico humanitieshistory and archaeologyhistorymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesmedical and health sciencesbasic medicinepathology Programma(i) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) INCO-2004-A1.3 - Knowledge and technologies to improve control of neglected communicable diseases Invito a presentare proposte FP6-2004-INCO-DEV-3 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITY OF YORK Contributo UE Nessun dato Indirizzo Heslington YORK Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto HOPITAL ALBERT SCHWEITZER Gabon Contributo UE Nessun dato Indirizzo LAMBARENE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Leiden University Medical Center Paesi Bassi Contributo UE Nessun dato Indirizzo Albinusdreef 2 LEIDEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NOGUCHI MEMORIAL INSTITUTE FOR MEDICAL RESEARCH Ghana Contributo UE Nessun dato Indirizzo Legon ACCRA Mostra sulla mappa Costo totale Nessun dato PRINCE LEOPOLD INSTITUTE OF TROPICAL MEDICINE Belgio Contributo UE Nessun dato Indirizzo Nationalestraat 155 ANTWERP Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITE CHEIKH ANTA DIOP Senegal Contributo UE Nessun dato Indirizzo Avenue Martin Luther King DAKAR FANN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
