Final Report Summary - TRIFLU (Trifluoromethylation under Photoredox Catalysis)
Fluorine chemistry is critically important to advance a range of fields inclusive of medicinal chemistry, agrochemical chemistry as well as material science. In this context, there is a demand for new methods for the late stage selective trifluoromethylation of substrates that are not activated by
the prototypical carbonyl group functionality. Such substrates require new catalytic manifolds to enhance reactivity and allow control over selectivity (regioselectivity, diastereoselectivity, chirality transfer, enantioselectivity).
This study aimed at an in-depth understanding of reaction mechanisms (featuring cyclic voltammetric measurements and electrochemistry) and generation of a library of compounds, the properties of which will be examined for potential application in drug discovery.
The project contributes to advance catalysis in Europe and beyond.
the prototypical carbonyl group functionality. Such substrates require new catalytic manifolds to enhance reactivity and allow control over selectivity (regioselectivity, diastereoselectivity, chirality transfer, enantioselectivity).
This study aimed at an in-depth understanding of reaction mechanisms (featuring cyclic voltammetric measurements and electrochemistry) and generation of a library of compounds, the properties of which will be examined for potential application in drug discovery.
The project contributes to advance catalysis in Europe and beyond.