Objectif Healthy functionality in the brain relies on intricate neuron-glia networks. Recent data suggest that glial, including astrocytes, play a crucial role in the processing and storing on by the brain. In particular, synapses might not be bipartite, but rather tripartite structures, comprised of the pre- and the postsynaptic terminals and the surrounding astrocyte. Moreover, astrocytes, like neurons, form intricate interconnected networks that afford long-range communication via the propagation of calcium waves. Therefore, neurons and astrocytes form intertwined neuron-glial networks supporting active partnership between the two cell populations. Hence, understanding the nature of neuron-glia interactions is essential to understand how the brain functions, and will serve as a stepping stone for deciphering brain disorders.Our long-term goal is to reveal the mechanisms that control and regulates the activity of combined neuron-glia networks. The specific objectives of this application, which are fundamental in the pursuit of that goal, are (1) to determine the properties of astrocytic modulation of synaptic transmission; and (2) to characterize how such modulation shapes neuronal activity in neuron-glia networks of the brain.To pursue these aims we will employ a comprehensive theoretical investigation to develop mathematical and biophysical models in support to experiments, at the many levels and scales of action of neuron-astrocyte signaling.The significance of understanding glia-neuron interactions is several-fold as it pertains to a very wide range of applications, from basic understanding of neuronal activity, to developing therapeutic strategies toward the treatment of neurological disorders. Here, we will focus on how modulations of synaptic transmission by astrocytes could favor the emergence of synchronized neuronal, leveraging the predictions of our theoretical approach in the perspective of brain disorders, and epilepsy in particular. Champ scientifique medical and health sciencesbasic medicineneurologyepilepsynatural scienceschemical sciencesinorganic chemistryalkaline earth metals Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2012-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2012-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE Contribution de l’UE € 268 781,10 Adresse DOMAINE DE VOLUCEAU ROCQUENCOURT 78153 Le Chesnay Cedex France Voir sur la carte Région Ile-de-France Ile-de-France Yvelines Type d’activité Research Organisations Contact administratif Muriel Amiel (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée