Objectif
"The present project aims at casting light on the neural and cognitive reorganization of visual function following unilateral lesion at various levels of the central visual system such as optic tract, optic radiation, primary visual cortex, extrastriate visual areas. In the first part of the project we will employ behavioural as well as brain imaging methods to study the basic neural mechanisms of blindsight, that is, above chance visually guided behaviour in hemianopic patients in the absence of visual awareness. The neural and cognitive substrate of this condition will be compared with that of conscious vision in order to tease apart the neural and cognitive mechanisms responsible of the shift from unconscious to conscious vision. In addition to purely behavioural experiments all patients will be tested while recording, in planned sequential experiments, ERP, MEG and fMRI to assess the processing stage and the brain areas subserving unconscious and conscious vision, respectively. This procedure will enable us to correlate the level of perceptual awareness retained or acquired and the lesion site. In the second part of the project we will use visual imagery to ""access"" the deafferented or lesioned visual cortex. By means of fMRI and MEG recording we will assess the effect on specific cortical areas of focusing a mental visual image on given portions of either the intact or the hemianopic field. The results of this procedure will constraint the development of novel imagery-based visual rehabilitation protocols tailored individually on the basis of the lesion profile of the patients and on the presence of concurrent brain imaging feedback on the plastic cortical changes occurred as a result of specific training."
Champ scientifique
Appel à propositions
ERC-2013-ADG
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Régime de financement
ERC-AG - ERC Advanced GrantInstitution d’accueil
37129 Verona
Italie