Transcriptional regulation and cellular localization of mycobacterial cell cycle proteins during dormancy

Projektinformationen

MYCOMANCY

ID Finanzhilfevereinbarung: 37566

Projekt abgeschlossen

Startdatum 1 November 2006

Enddatum 30 April 2009

Finanziert unter

• Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Gesamtkosten € 1 168 991,00

EU-Beitrag € 835 875,00

Koordiniert durch

UNIVERSITÀ DEGLI STUDI PADOVA
Italy

Ziel

In this project we propose to study the relation between the cell cycle and dormancy development in Mycobacterium tuberculosis (Mtb).
The final aim is to increase the knowledge on dormancy development and to identify potential candidates for the development of antitubercular drugs specifically active in dormant bacilli. Mtb is a facultative intracellular pathogen able to infect the human lung for decades without showing any symptom. Following immunity suppression caused by age, diseases, or malnutrition, tubercle bacilli can reactivate to give overt disease.
About one third of the human population is estimated to be affected by latent tuberculosis representing a huge reservoire for the infection. The lack of drugs efficiently active on dormant bacteria is a major problem in fighting this important disease.
Conditional mutants unable to express important cell cycle regulators will be constructed and used to study their role in
i) global regulation of gene expression; ii) cell cycle proteins cytolocalization;
iii) latency development in vitro and in vivo.
Additionally, a transposon insertion library will be used to identify new mycobacterial genes essential for survival to prolonged stationary phase, and their expression will be measured during progressive and latent infection.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programm/Programme

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Thema/Themen

• LSH-2005-2.3.0-4 - New approaches for research into host/vector-pathogen interaction for HIV/AIDS, malaria and tuberculosis
• LIFESCIHEALTH - Life sciences, genomics and biotechnology for health

Aufforderung zur Vorschlagseinreichung

FP6-2005-LIFESCIHEALTH-6
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

STREP - Specific Targeted Research Project

Koordinator

UNIVERSITÀ DEGLI STUDI PADOVA

• EU-Beitrag: Keine Daten
• Adresse: Via 8 Febbraio, 2 ; PADOVA ; Italien
• Gesamtkosten: Keine Daten

Beteiligte (4)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spanien

• EU-Beitrag: Keine Daten
• Adresse: SERRANO 117 ; MADRID
• Gesamtkosten: Keine Daten

INSERM

Frankreich

• EU-Beitrag: Keine Daten
• Adresse: 156 rue de Vaugirard ; PARIS
• Gesamtkosten: Keine Daten

INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS

Venezuela

• EU-Beitrag: Keine Daten
• Adresse: Km 11 Carretera Panamericana ; ESTADO MIRANDA
• Gesamtkosten: Keine Daten

NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION "SALVADOR ZUBIRAN"

Mexiko

• EU-Beitrag: Keine Daten
• Adresse: Vasco de Quiroga NO. 15, Col. Seccion XVI ; MEXICO CITY
• Gesamtkosten: Keine Daten