Cel Vertebrate development is orchestrated by the coordinated deployment of multiple and diverse programs of cell commitment and differentiation. One of the fundamental questions in this process is how a discrete number of transcriptional programs and extracellular cues combine to produce the enormous cellular complexity that characterizes vertebrate organisms. This research aims at uncovering the general principles of how cellular diversity is created in the sensory nervous system.We aim to determine: 1/ the transcriptional programs directing the commitment and differentiation of different types of sensory neurons and 2/ how, when and where different types of sensory neurons are committed by genetic tracing. The proposed research takes advantage of multidisciplinary approaches including model systems and methods such as rapid screening of gene function in the chick, a boundary cap neural stem cell culture system, and advanced mouse genetics for revealing gene function and for lineage tracing. Dziedzina nauki natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurology Słowa kluczowe Cell Type Specification Neural Crest Sensory System Stem Cells Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Zaproszenie do składania wniosków FP6-2005-MOBILITY-5 Zobacz inne projekty w ramach tego zaproszenia System finansowania EIF - Marie Curie actions-Intra-European Fellowships Koordynator KAROLINSKA INSTITUTET Wkład UE Brak danych Adres Nobels väg 5 STOCKHOLM Szwecja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
