Obiettivo The main objective of this 4 years IP is the development, up to clinical phase I, of a specific HIV microbicide for the prevention of sexual transmission/acquisition of HIV, based on the interruption of viral replication at the mucosal level. Some members of a new class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), the DABOs, proved capable of irreversibly knocking out HIV-1 replication. This property correlates with their ability to tightly bind to the HIV-1 Reverse Transcriptase. The lead compound of these series of tight binding NNRTIs is MC1220. The organisation of this project comprises 3 discovery chemistry teams combined with a 3D modelling team who will investigate other compounds for back up and combination purposes.The global preclinical and pharmaceutical workflow is organized to permit very rapid access to formulation screening and challenge efficacy model in the macaque in 2 centres, 1 in Europe, 1 in Africa. Finally the clinical phase I trial will involve HIV medical teams very implicated towards development of clinical trialand treatment networks in Africa. The work programme is organised in i) the research engine for validation of concept of MC1220 as a microbicide in in-vitro assays & for the design / synthesis optimisation of DABOs & uracil based NNRTIs ii) for pharmaceutical and preclinical development of candidate lead compound, iii) formulation screening and challenge efficacy model for proof of principle in a validate primate model for vaginal RT-SHIV challenge and iv) studies and tasks directly aimed at conducting Phase I tolerability studies in women. 11 partners, from academy to industry will contribute to the project & focus both on respect of timing and achievement of expected objectives, as well as to widespread scientific results and economical benefits to achieve all scientific andregulatory requirements to go to phase II clinical trial programmes within EDCTP or Alliance for microbicide for example. Campo scientifico natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV Parole chiave HIV animal models clinical trial women drug development microbicide mucosal Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2002-2.3.0-2 - HIV microbicides Invito a presentare proposte FP6-2002-LIFESCIHEALTH Vedi altri progetti per questo bando Meccanismo di finanziamento IP - Integrated Project Coordinatore UNIVERSITA' DEGLI STUDI DI CAGLIARI Contributo UE Nessun dato Indirizzo Cittadella Univesitaria, SS 554 km 4,500 MONSERRATO (CA) Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" Italia Contributo UE Nessun dato Indirizzo P. Le Aldo Moro, 5 Box36 Roma62 ROMA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF SOUTHERN DENMARK Danimarca Contributo UE Nessun dato Indirizzo 55 Campusvej ODENSE M Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITE DE LA MEDITERRANEE-CNRS-AFMB Francia Contributo UE Nessun dato Indirizzo 58, Bd CHarles Livon, Jardin du Pharo MARSEILLE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato LABORATOIRES IDENIX Francia Contributo UE Nessun dato Indirizzo 170 Rue Leon BLUM MONTPELLIER Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF PATRAS Grecia Contributo UE Nessun dato Indirizzo University Campus RIO-ACHAIA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato DEUTSCHES PRIMATENZENTRUM GMBH Germania Contributo UE Nessun dato Indirizzo Kellnerweg 4 GOETTINGEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CENTRE INTERNATIONAL DE RECHERCHES MEDICALES DE FRANCEVILLE Gabon Contributo UE Nessun dato Indirizzo 769 FRANCEVILLE Mostra sulla mappa Costo totale Nessun dato UNIVERSITA DI MILANO Italia Contributo UE Nessun dato Indirizzo Via Festa del Perdono, 7 MILANO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT Francia Contributo UE Nessun dato Indirizzo 209 rue Lafayette PARIS Mostra sulla mappa Costo totale Nessun dato ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS Francia Contributo UE Nessun dato Indirizzo 3 avenue Victoria PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato