Obiettivo BACKGROUND: Proteinuria is a sign of kidney involvement in association with common infectious, inflammatory, immunological or metabolic (diabetes) diseases. When persisting, proteinuria leads to scarring and end-stage kidney disease requiring dialysis or renal transplantation. Both treatments are chronically debilitating, increase risk for severe secondary complications and are extremely expensive. Altogether, kidney complicationsconstitute more than 15% of total health-care costs in most Western countries, mainly due to increasing prevalence of diabetes-associated kidney disease.PROBLEM: Earlier diagnostics is urgently needed to target intensive treatment efforts and to avoid the projectedexplosive increase in the number of kidney patients in near future. Due to the demographic trends, kidney diseases are a particular problem for Europe. At present, the diagnostics include serum markers (mostly non- sensitive, non-specific) and urine analysis (too late markers) but relies mainly on patient kidney biopsy samples. Although accurate, this procedure is severely inconvenient, invasive and carries a notable risk for complications.SOLUTION: We propose to use the latest molecular information of verified pathogenetic routes, proprietary bio informatics platforms, well established in vivo models as well as extensive human sample repositories together with the SME activities to establish and validate new diagnostics. This includes the identification of an expanding set of key molecular markers directly from patient urine to yield novel measurable for early and accurate non-invasive diagnostics. With the set of markers accurately reflecting pathophysiologic changes we expect to replace the traditional kidney biopsies with more patient-friendly, accurate and economical diagnostics directly from urine, easily accessible source. Development will also allow construction of distant monitoring diaqnostic platforms to prevent permanent kidney. Campo scientifico social sciencessociologydemographymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinetransplantationmedical and health sciencesclinical medicinenephrologykidney diseases Parole chiave bioinformatics dialysis experimental models glomerulus kidney proteinuria transplantation Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2002-1.2.2-2 - Development of novel non-invasive and repeatable diagnostics using bioinformatics tools Invito a presentare proposte FP6-2002-LIFESCIHEALTH Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore HELSINGIN YLIOPISTO Contributo UE Nessun dato Indirizzo Yliopistonkatu 4 HELSINKI Finlandia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Germania Contributo UE Nessun dato Indirizzo Hansastrasse 27C MUENCHEN Mostra sulla mappa Costo totale Nessun dato SAMFUNDET FOLKHAELSAN I SVENSKA FINLAND R.F. Finlandia Contributo UE Nessun dato Indirizzo Topeliuksenkatu, 20 211 HELSINKI Mostra sulla mappa Costo totale Nessun dato UNIVERSIDAD AUTONOMA DE MADRID Spagna Contributo UE Nessun dato Indirizzo Campus de Cantoblanco, Carretera de Colmenar Viejo Km. 15 MADRID Mostra sulla mappa Costo totale Nessun dato TEKNILLINEN KORKEAKOULU Finlandia Contributo UE Nessun dato Indirizzo Otakaari 1 1000 ESPOO Mostra sulla mappa Costo totale Nessun dato CIPHERGEN BIOSYSTEM A/S Danimarca Contributo UE Nessun dato Indirizzo Symbion Research Park, Fruebjergvej 3 COPENHAGEN Mostra sulla mappa Costo totale Nessun dato