Final Activity Report Summary - COMBICHEM-GIRONA (Synthesis of pyrimidine and spiroimidazolidinone libraries by combinatorial chemistry)
On the other hand, we set up a methodology for the rapid and efficient solid-phase synthesis of spiroimidazolidinones, in particular, of novel 1,4,8-triazaspiro[4.5]decan-2-one derivatives. We optimised the preparation of 1,4,8-triazaspiro[4.5]decan-2-one-1-acetamides substituted at 4 and 8 positions as well as the preparation of 4-aryl-8-benzyl-1,4,8-triazaspiro[4.5]decan-2-ones substituted at position 1. Both optimization studies were performed by the Multipin technology using SynphaseTM Lanterns as solid support. This methodology was used for the preparation of a collection of novel spiroimidazolidinone derivatives.