Objective Recent developments in the analysis of synchronization and directionality of couplings for nonlinear and chaotic oscillators will be applied to study the complex interactions between brain waves and cardio-respiratory oscillations during anaesthesia. Pre liminary studies have shown that marked changes occur in the inter-oscillator interactions during anaesthesia. These could form a new bases for measurement of anaesthesia. An interdisciplinary consortium of scientist will carry out and analyse experiment s on humans and rats. The work will involve (i) further development of methods for analyses of complex interactions, (ii) measurements and data collection, (iii) time series analysis, (iv) mathematical modelling of interactions between coupled oscillato rs, and (v) neurological, physiological and clinical interpretation of mechanisms of inter-oscillator couplings during anaesthesia and consciousness. Causal relationships between the oscillatory processes will be evaluated for various stages of anaesthesi a and consciousness. Protocols will be prepared for a larger scale study that will follow and will aim at standardising the measures for depth of anaesthesia based on inter-oscillators couplings. The tools developed during this research programme will be directly applicable to anaesthesiology, cardiovascular studies, neurology and physiology, but will also be useful for reviling complex interactions quite generally, e.g. in meteorology, geology, sociology and economics. Fields of science medical and health sciencesclinical medicineanaesthesiology Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) NEST-2003-Path-1 - Complex systems Call for proposal FP6-2003-NEST-PATH See other projects for this call Funding Scheme NoE - Network of Excellence Coordinator LANCASTER UNIVERSITY EU contribution No data Address Bailrigg LANCASTER United Kingdom See on map Links Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution No data Address Ecublens LAUSANNE See on map Links Website Opens in new window Total cost No data MORECAMBE BAY HOSPITALS NHS TRUST United Kingdom EU contribution No data Address Westmorland General Hospital, BURTON ROAD KENDAL See on map Total cost No data ULLEVAEL UNIVERSITY HOSPITAL Norway EU contribution No data Address Kirkeveien, 166 OSLO See on map Links Website Opens in new window Total cost No data UNIVERSITAET POTSDAM Germany EU contribution No data Address Am Neuen Palais 10 POTSDAM See on map Links Website Opens in new window Total cost No data UNIVERZA V LJUBLJANI Slovenia EU contribution No data Address Kongresni trg 12 LJUBLJANA See on map Links Website Opens in new window Total cost No data USTAV INFORMATIKY AVCR Czechia EU contribution No data Address POD VODARENSKOU VEZI 2 PRAGUE 8 See on map Links Website Opens in new window Total cost No data