Objectif Normal physiology depends on defined functional output of differentiated cells. A century of Developmental–Biology studies revealed diverse mechanisms for differentiation, however once ‘terminally’ differentiated, cells are thought to naïvely stay put. However differentiated cells are surprisingly fragile, for example, phenotypic collapse and de–differentiation of β–cells was recently discovered in pathogenesis of type 2 diabetes. These discoveries necessitate investigations of key questions: How is cell–type identity robustly maintained for decades in the adult organism? What are the genetic mechanisms for continuous maintenance of differentiation and identity? microRNAs, are known to impart robustness to differentiation. Do they play important roles in maintenance of adult β–cell identity?Our overarching objective is to explore the exciting hypotheses that(i) Networks of microRNA and protein–coding genes are required to maintain adult cell identity.(ii) microRNAs confer robustness to adult β–cell identity by repressing disallowed genes that are deleterious to β–cells.(iii) Dysregulated microRNA disrupt cell identity and is a likely vector of pathology.Our planned research has the potential of producing conceptual breakthroughs including:(1) Revolutionary view of microRNAs as agents of adult cell identity and discoveries of specific microRNAs that are crucial for maintaining β–cell identity(2) Experimental discovery of targets and networks involved in adult β–cell de-differentiation.(3) In–vivo evidence for combinatorial action of multiple microRNAs in control of β–cell identity.(4) Uncovering new links from de–differentiation and into metabolic diseases that may drive future medical innovation through usage of small RNAs to reinforce β–cell differentiation. Champ scientifique natural sciencesbiological sciencesdevelopmental biologymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-CG-2013-LS4 - ERC Consolidator Grant - Physiology, Pathophysiology and Endocrinology Appel à propositions ERC-2013-CoG Voir d’autres projets de cet appel Régime de financement ERC-CG - ERC Consolidator Grants Institution d’accueil WEIZMANN INSTITUTE OF SCIENCE Contribution de l’UE € 2 000 000,00 Adresse HERZL STREET 234 7610001 Rehovot Israël Voir sur la carte Type d’activité Higher or Secondary Education Establishments Chercheur principal Eran Hornstein (Dr.) Contact administratif Gabi Bernstein (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire WEIZMANN INSTITUTE OF SCIENCE Israël Contribution de l’UE € 2 000 000,00 Adresse HERZL STREET 234 7610001 Rehovot Voir sur la carte Type d’activité Higher or Secondary Education Establishments Chercheur principal Eran Hornstein (Dr.) Contact administratif Gabi Bernstein (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
