Project description
Stratification of patients with the endocrine form of hypertension
Arterial hypertension affects almost half of the general population. Despite a significant therapeutic arsenal, blood pressure control is not effective in many patients. Even small increments in blood pressure can increase cardiovascular risk, highlighting the importance of detecting secondary forms of hypertension to prevent cardiovascular complications. Endocrine forms of hypertension include a group of adrenal disorders characterised by increased production of hormones that affect blood pressure regulation. They are associated with increased cardiovascular and metabolic risk. The EU-funded EVSAT-HT project will develop and evaluate an omics-based stratification program for patients with endocrine forms of hypertension based on omics-based profiling. This approach should allow the identification of patients from specific endocrine groups who may benefit from personalised treatment.
Objective
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension.
Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life.
This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
75654 Paris
France