Objectif
Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.
Champ scientifique
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- social scienceseconomics and businessbusiness and managemententrepreneurship
- medical and health sciencesclinical medicineoncology
- medical and health scienceshealth sciencesinfectious diseasesDNA viruses
Programme(s)
Régime de financement
MSCA-ITN-ETN - European Training NetworksCoordinateur
1081 HV Amsterdam
Pays-Bas
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Participants (9)
NG7 2RD Nottingham
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G12 8QQ Glasgow
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97070 Wuerzburg
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75794 Paris
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Participation terminée
80539 Munchen
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75654 Paris
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28049 Madrid
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B-9052 ZWIJNAARDE
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L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.
1081HV AMSTERDAM
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L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.
Partenaires (6)
Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention.
4123 ALLSCHWIL
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Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention.
BT63 5QD CRAIGAVON
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Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention.
30200 CODOLET
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Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention.
6041 Gosselies
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Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention.
3011 BN Rotterdam
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Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention.
47001 VALLADOLID
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