Objective The key therapeutic issue in diabetes mellitus type I and II is glycaemic control. Reductions of constant self-control, of insulin injections, and of long-term complications would have tremendous benefit for quality of life. The best therapy option is the transplantation of allogeneic islet cells, but the current state of the art limits the applicability of this approach. Implanting unprotected grafts requires lifelong administration of immunosuppressants, and protecting the cells against adverse immune reactions by current encapsulation strategies reduces their functionality and survival to an extend that makes frequent ‘refresher’ implantations necessary. Currently, a maximum of 2 years glycaemia regulation has been shown for the encapsulated approach.In BIOCAPAN, bringing experts from different fields all together, we aim at developing an innovative treatment, based on the implantation of allogeneic islet cells that are embedded in a complex microcapsule. We will design a GMP-grade bioactive microcapsule that will maximize the long-term functionality and survival of pancreatic islets by prevention of pericapsular fibrotic overgrowth, in situ oxygenation, innovative extracellular matrix microenvironment reconstruction and immune-system modulation. We will establish a GMP-grade microfluidic microencapsulation platform to protect freshly harvested islets quickly in a standardized and reproducible way.We aim for full preclinical validation and we will establish a complete protocol in accordance with the provisions of the Advanced Therapy Medicinal Products Regulation, in order to start clinical trials within one year after the end of the project. We aim for 5-years insulin injection free treatment, without immunosuppressants, which would tremendously benefit diabetes mellitus patients who require insulin (all Type I and about one in six Type II Diabetes Mellitus patients). Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologytissue engineeringartificial pancreascontinuous glucose monitorsmedical and health sciencesclinical medicinetransplantationmedical and health sciencesmedical biotechnologycells technologies Programme(s) H2020-EU.2.1.3. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials Main Programme H2020-EU.2.1.3.1. - Cross-cutting and enabling materials technologies Topic(s) NMP-10-2014 - Biomaterials for the treatment of diabetes mellitus Call for proposal H2020-NMP-2014-2015 See other projects for this call Sub call H2020-NMP-2014-two-stage Funding Scheme RIA - Research and Innovation action Coordinator COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Net EU contribution € 1 988 570,00 Address RUE LEBLANC 25 75015 PARIS 15 France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 988 570,00 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium Net EU contribution € 1 364 915,00 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 364 915,00 CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany Net EU contribution € 1 194 291,25 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 194 291,25 FMC BIOPOLYMER AS Norway Net EU contribution € 236 861,25 Address INDUSTRIVEIEN 33 1337 SANDVIKA See on map Region Norge Oslo og Viken Viken Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 236 861,25 NANOIMMUNOTECH SL Spain Net EU contribution € 853 225,00 Address EDIFICIO CITEXVI C FONTE DAS ABELLE SN CAMPUS UNIVERSITARIO DE VIGO 36310 Vigo Pontevedra See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noroeste Galicia Pontevedra Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 853 225,00 UNIVERSITE GRENOBLE ALPES France Net EU contribution € 721 378,75 Address 621 AVENUE CENTRALE 38058 Grenoble See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 783 878,75 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE France Net EU contribution € 62 500,00 Address BOULEVARD DE LA CHANTOURNE 38700 La Tronche See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 62 500,00 ETABLISSEMENT FRANCAIS DU SANG France Net EU contribution € 652 940,00 Address AVENUE DU STADE DE FRANCE 20 93210 La Plaine Saint Denis See on map Region Ile-de-France Ile-de-France Seine-Saint-Denis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 652 940,00 EUROPEAN RESEARCH SERVICES GMBH Germany Net EU contribution € 159 275,00 Address HUEFFERSTR. 5 48149 Muenster See on map Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 159 275,00 WAKE FOREST UNIVERSITY HEALTH SCIENCES United States Net EU contribution € 764 918,75 Address MEDICAL CENTER BOULEVARD 27157 WINSTON SALEM NC See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 764 918,75