Mathematical Optimization for clinical DEcision Support and Training

Project Information

MODEST

Grant agreement ID: 647573

DOI 10.3030/647573

Project closed

EC signature date 9 April 2015

Start date 1 July 2015

End date 30 June 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 998 500,00

EU contribution € 1 998 500,00

Coordinated by

OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Germany

Publications

Peer reviewed articles (21)

Mixed-integer optimal control under minimum dwell time constraints

Author(s): Clemens Zeile, Nicolò Robuschi, Sebastian Sager
Published in: Mathematical Programming, 2020, ISSN 0025-5610
Publisher: Springer Verlag
DOI: 10.1007/s10107-020-01533-x

Model-Based Simulation of Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia

Author(s): Felix Jost, Jakob Zierk, Thuy T. T. Le, Thomas Raupach, Manfred Rauh, Meinolf Suttorp, Martin Stanulla, Markus Metzler, Sebastian Sager
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00217

Spatial relationship between the pulmonary trunk and the left coronaries: Systematic risk assessment based on automated three-dimensional distance measurements

Author(s): Eberhard Scholz, Christa Hartlage, Felix Bernhardt, Tobias Weber, Janek Salatzki, Florian André, Patrick Lugenbiel, Johannes Riffel, Hugo Katus, Sebastian Sager
Published in: Heart Rhythm O2, Issue 1/1, 2020, Page(s) 14-20, ISSN 2666-5018
Publisher: Elsevier
DOI: 10.1016/j.hroo.2020.02.001

Multiphase mixed-integer nonlinear optimal control of hybrid electric vehicles

Author(s): Nicolò Robuschi, Clemens Zeile, Sebastian Sager, Francesco Braghin
Published in: Automatica, Issue 123, 2021, Page(s) 109325, ISSN 0005-1098
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.automatica.2020.109325

A Feedback Optimal Control Algorithm with Optimal Measurement Time Points

Author(s): Felix Jost, Sebastian Sager, Thuy Le
Published in: Processes, Issue 5/4, 2017, Page(s) 10, ISSN 2227-9717
Publisher: MDPI AG
DOI: 10.3390/pr5010010

Novel algorithm for accelerated electroanatomic mapping and prediction of earliest activation of focal cardiac arrhythmias using mathematical optimization

Author(s): Tobias Weber, Hugo A. Katus, Sebastian Sager, Eberhard P. Scholz
Published in: Heart Rhythm, Issue 14/6, 2017, Page(s) 875-882, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2017.03.001

A web-based feedback study on optimization-based training and analysis of human decision making

Author(s): Michael Engelhart, Joachim Funke, Sebastian Sager
Published in: Journal of dynamic decision making, Issue Vol.3, 2017, ISSN 2365-8037
Publisher: JDDM
DOI: 10.11588/jddm.2017.1.34608

Optimum Experimental Design for Patient Specific Mathematical Leukopenia Models * *This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 647573), which is gratefully acknowledged.

Author(s): Felix Jost, Kristine Rinke, Thomas Fischer, Enrico Schalk, Sebastian Sager
Published in: IFAC-PapersOnLine, Issue 49/26, 2016, Page(s) 344-349, ISSN 2405-8963
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2016.12.150

Parameter estimation for leukocyte dynamics after chemotherapy * *This research was supported by a research grant of the “nternational Max Planck Research School (IMPRS) for Advanced Methods in Process and System Engineering (Magdeburg)” and from the European Research Council via the Consolidator Grant MODEST-647573.

Author(s): Kristine Rinke, Felix Jost, Rolf Findeisen, Thomas Fischer, Rainer Bartsch, Enrico Schalk, Sebastian Sager
Published in: IFAC-PapersOnLine, Issue 49/26, 2016, Page(s) 44-49, ISSN 2405-8963
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2016.12.101

A Simplified 2D Heart Model of the Wolff-Parkinson-White Syndrome

Author(s): Clemens Zeile, Eberhard Scholz, Sebastian Sager
Published in: IFAC-PapersOnLine, Issue 49/26, 2016, Page(s) 26-31, ISSN 2405-8963
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2016.12.098

Mathematical Modeling of RBC Count Dynamics after Blood Loss

Author(s): Manuel Tetschke, Patrick Lilienthal, Torben Pottgiesser, Thomas Fischer, Enrico Schalk, Sebastian Sager
Published in: Processes, Issue 6/9, 2018, Page(s) 157, ISSN 2227-9717
Publisher: MDPI AG
DOI: 10.3390/pr6090157

Optimal Control of Vibration-Based Micro-energy Harvesters

Author(s): Thuy T. T. Le, Felix Jost, Sebastian Sager
Published in: Journal of Optimization Theory and Applications, Issue 179/3, 2018, Page(s) 1025-1042, ISSN 0022-3239
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10957-018-1250-4

A mathematical model of white blood cell dynamics during maintenance therapy of childhood acute lymphoblastic leukemia

Author(s): Thuy T T Le, Felix Jost, Thomas Raupach, Jakob Zierk, Manfred Rauh, Meinolf Suttorp, Martin Stanulla, Markus Metzler, Sebastian Sager
Published in: Mathematical Medicine and Biology: A Journal of the IMA, Issue 36/4, 2018, Page(s) 471-488, ISSN 1477-8599
Publisher: Oxford University Press
DOI: 10.1093/imammb/dqy017

Global optimal control with the direct multiple shooting method

Author(s): H. Diedam, S. Sager
Published in: Optimal Control Applications and Methods, Issue 39/2, 2018, Page(s) 449-470, ISSN 0143-2087
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/oca.2324

The asymptotic error of chaos expansion approximations for stochastic differential equations

Author(s): Tony Huschto, Mark Podolskij, Sebastian Sager
Published in: Modern Stochastics: Theory and Applications, 2019, Page(s) 145-165, ISSN 2351-6046
Publisher: VTEX
DOI: 10.15559/19-vmsta133

Solving quadratic programs to high precision using scaled iterative refinement

Author(s): Tobias Weber, Sebastian Sager, Ambros Gleixner
Published in: Mathematical Programming Computation, Issue 11/3, 2019, Page(s) 421-455, ISSN 1867-2949
Publisher: Springer Verlag
DOI: 10.1007/s12532-019-00154-6

Design, implementation and simulation of an MPC algorithm for switched nonlinear systems under combinatorial constraints

Author(s): Adrian Bürger, Clemens Zeile, Angelika Altmann-Dieses, Sebastian Sager, Moritz Diehl
Published in: Journal of Process Control, Issue 81, 2019, Page(s) 15-30, ISSN 0959-1524
Publisher: Butterworth Scientific Ltd.
DOI: 10.1016/j.jprocont.2019.05.016

Mathematical models for cytarabine-derived myelosuppression in acute myeloid leukaemia

Author(s): Felix Jost, Enrico Schalk, Kristine Rinke, Thomas Fischer, Sebastian Sager
Published in: PLOS ONE, Issue 14/7, 2019, Page(s) e0204540, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0204540

Model-based optimal AML consolidation treatment

Author(s): Felix Jost, Enrico Schalk, Daniela Weber, Hartmut Dohner, Thomas Fischer, Sebastian Sager
Published in: IEEE Transactions on Biomedical Engineering, 2020, Page(s) 1-1, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2020.2982749

CO2 methanation process synthesis by superstructure optimization

Author(s): Jennifer Uebbing, Liisa Rihko-Struckmann, Sebastian Sager, Kai Sundmacher
Published in: Journal of CO2 Utilization, Issue 40, 2020, Page(s) 101228, ISSN 2212-9820
Publisher: Elsevier BV
DOI: 10.1016/j.jcou.2020.101228

Optimized and Personalized Phlebotomy Schedules for Patients Suffering From Polycythemia Vera

Author(s): Patrick Lilienthal, Manuel Tetschke, Enrico Schalk, Thomas Fischer, Sebastian Sager
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00328

Thesis and dissertations (1)

Inverse Simulation for Cardiac Arrhythmia

Author(s): Florian Kehrle
Published in: PhD thesis, 2018
Publisher: Otto-von-Guericke Universität

Other (1)

Optimization and Clinical Decision Support

Author(s): Sebastian Sager
Published in: Optima Newsletter, Issue 104, 2018, Page(s) 1-8
Publisher: Mathematical Optimisation Society