Engineering Complex Intestinal Epithelial Tissue Models

Project Information

COMIET

Grant agreement ID: 647863

DOI 10.3030/647863

Project closed

EC signature date 9 November 2015

Start date 1 December 2015

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 997 190,00

EU contribution € 1 997 190,00

Coordinated by

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

Publications

Peer reviewed articles (14)

Editorial: When the Shape Does Matter: Three-Dimensional In Vitro Models of Epithelial Barriers

Author(s): Vanesa Fernández-Majada, María García-Díaz, Núria Torras, Michael Raghunath, Elena Martínez
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers in bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.617361

Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering

Author(s): Verónica Hortigüela, Enara Larrañaga, Francesco Cutrale, Anna Seriola, María García-Díaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena Martínez
Published in: Nano Letters, Issue 18/1, 2017, Page(s) 629-637, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.7b04904

Eph-ephrin signaling modulated by polymerization and condensation of receptors

Author(s): Samuel Ojosnegros, Francesco Cutrale, Daniel Rodríguez, Jason J. Otterstrom, Chi Li Chiu, Verónica Hortigüela, Carolina Tarantino, Anna Seriola, Stephen Mieruszynski, Elena Martínez, Melike Lakadamyali, Angel Raya, Scott E. Fraser
Published in: Proceedings of the National Academy of Sciences, Issue 114/50, 2017, Page(s) 13188-13193, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1713564114

Using enhanced number and brightness to measure protein oligomerization dynamics in live cells

Author(s): Francesco Cutrale, Daniel Rodriguez, Verónica Hortigüela, Chi-Li Chiu, Jason Otterstrom, Stephen Mieruszynski, Anna Seriola, Enara Larrañaga, Angel Raya, Melike Lakadamyali, Scott E. Fraser, Elena Martinez, Samuel Ojosnegros
Published in: Nature Protocols, Issue 14/2, 2019, Page(s) 616-638, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-018-0111-9

Mimicking Epithelial Tissues in Three-Dimensional Cell Culture Models

Author(s): Núria Torras, María García-Díaz, Vanesa Fernández-Majada, Elena Martínez
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, Page(s) 1-7, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2018.00197

Dynamic photopolymerization produces complex microstructures on hydrogels in a moldless approach to generate a 3D intestinal tissue model

Author(s): Albert G Castaño, María García-Díaz, Núria Torras, Gizem Altay, Jordi Comelles, Elena Martínez
Published in: Biofabrication, Issue 11/2, 2019, Page(s) 025007, ISSN 1758-5090
Publisher: Institute of Physics Pub.
DOI: 10.1088/1758-5090/ab0478

Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies

Author(s): Verónica Hortigüela, Enara Larrañaga, Anna Lagunas, Gerardo A. Acosta, Fernando Albericio, Jordi Andilla, Pablo Loza-Alvarez, Elena Martínez
Published in: Nanomaterials, Issue 9/4, 2019, Page(s) 579, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano9040579

Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function

Author(s): Gizem Altay, Enara Larrañaga, Sébastien Tosi, Francisco M. Barriga, Eduard Batlle, Vanesa Fernández-Majada, Elena Martínez
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-46497-x

Advanced bioengineering technologies for preclinical research

Author(s): Elena Martinez, Jean-Philippe St-Pierre, Fabio Variola
Published in: Advances in Physics: X, Issue 4/1, 2019, Page(s) 1622451, ISSN 2374-6149
Publisher: Taylor & Francis Online
DOI: 10.1080/23746149.2019.1622451

Imaging the Cell Morphological Response to 3D Topography and Curvature in Engineered Intestinal Tissues

Author(s): Gizem Altay, Sébastien Tosi, María García-Díaz, Elena Martínez
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.00294

Microfabrication of poly(acrylamide) hydrogels with independently controlled topography and stiffness

Author(s): Jordi Comelles, Vanesa Fernández-Majada, Núria Berlanga-Navarro, Verónica Acevedo, Karolina Paszkowska, Elena Martínez
Published in: Biofabrication, Issue 12/2, 2020, Page(s) 025023, ISSN 1758-5090
Publisher: IOPSCIENCE
DOI: 10.1088/1758-5090/ab7552

In vitro Self-organized Mouse Small Intestinal Epithelial Monolayer Protocol

Author(s): Gizem Altay, Eduard Batlle, Vanesa Fernández-Majada, Elena Martínez
Published in: BIO-PROTOCOL, Issue 10/3, 2020, ISSN 2331-8325
Publisher: Bio-protocol LLC
DOI: 10.21769/bioprotoc.3514

Hydrogel co-networks of gelatine methacrylate and poly(ethylene glycol) diacrylate sustain 3D functional in vitro models of intestinal mucosa

Author(s): Anna Vila, Núria Torras, Albert G Castaño, María García-Díaz, Jordi Comelles, Teresa Pérez-Berezo, Carmen Corregidor, Óscar Castaño, Elisabeth Engel, Vanesa Fernández-Majada, Elena Martínez
Published in: Biofabrication, Issue 12/2, 2020, Page(s) 025008, ISSN 1758-5090
Publisher: IOPSCIENCE
DOI: 10.1088/1758-5090/ab5f50

Engineering Tissue Barrier Models on Hydrogel Microfluidic Platforms

Author(s): Daniel Vera, María García-Díaz, Núria Torras, Mar Álvarez, Rosa Villa, Elena Martinez
Published in: ACS Applied Materials & Interfaces, Issue 13/12, 2021, Page(s) 13920-13933, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c21573

Non-peer reviewed articles (1)

Subepithelial Myofibroblasts Are Critical Regulators of Intestinal Epithelial Restoration

Author(s): Vanesa Fernández-Majada, Jordi Comelles, Verónica Acevedo, Aina Abad-Lázaro, Xavier Hernando-Momblona, Eduard Batlle, Elena Martinez
Published in: bioRxiv preprint, 2021, ISSN 2692-8205
Publisher: BiorXiv preprint server for biology
DOI: 10.1101/2021.05.28.446131