Description of information transfer across macromolecules by concerted conformational changes

Informazioni relative al progetto

CONCERT

ID dell’accordo di sovvenzione: 648201

DOI 10.3030/648201

Progetto chiuso

Data della firma CE 11 Giugno 2015

Data di avvio 1 Luglio 2015

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 950 000,00

Contributo UE € 1 950 000,00

Coordinato da

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain

Pubblicazioni

Peer reviewed articles (9)

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

Autori: Bouchard J. J., Otero J. H., Scott D. C., Szulc E. M., Martin E. W., Sabri N., Granata D., Marzahn M. R., Lindorff-Larsen K., Salvatella X., Schulman B. A., Mittag T.
Pubblicato in: Molecular Cell, 2018, Pagina/e 19-36, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2018.08.027

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Autori: Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen & Xavier Salvatella
Pubblicato in: Nature Communications, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09923-2

Bayesian-Maximum-Entropy reweighting of IDP ensembles based on NMR chemical shifts

Autori: Crehuet, Ramon; Buigues, Pedro J.; Salvatella, Xavier; Lindorff-Larsen, Kresten
Pubblicato in: Entropy, 2019, ISSN 1099-4300
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e21090898

Low amounts of heavy water increase the phase separation propensity of a fragment of the androgen receptor activation domain

Autori: Stasė Bielskutė; Carla Garcia-Cabau; Marta Frigolé-Vivas; Elzbieta Szulc; Eva De Mol; Mireia Pesarrodona; Jesús García; Xavier Salvatella
Pubblicato in: Protein Science, 2021, Pagina/e 1427-1437, ISSN 1469-896X
Editore: Wiley
DOI: 10.1002/pro.4110

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Autori: Eftekharzadeh, Bahareh; Banduseela, Varuna C.; Chiesa, Giulio; Martínez-Cristóbal, Paula; Rauch, Jennifer N.; Nath, Samir R.; Schwarz, Daniel M. C.; Shao, Hao; Marin-Argany, Marta; Di Sanza, Claudio; Giorgetti, Elisa; Yu, Zhigang; Pierattelli, Roberta; Felli, Isabella C.; Brun-Heath, Isabelle; García, Jesús; Nebreda, Ángel R.; Gestwicki, Jason E.; Lieberman, Andrew P.; Salvatella, Xavier
Pubblicato in: Nature Communications, 2019, Pagina/e 3562, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11594-y

Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Autori: Laura Cato, Antje Neeb, Adam Sharp, Victor Buzón, Scott B Ficarro, Linxiao Yang, Claudia Muhle-Goll, Nane C Kuznik, Ruth Riisnaes, Daniel Nava Rodrigues, Olivier Armant, Victor Gourain, Guillaume Adelmant, Emmanuel A Ntim, Thomas Westerling, David Dolling, Pasquale Rescigno, Ines Figueiredo, Friedrich Fauser, Jennifer Wu, Jaice T Rottenberg, Liubov Shatkina, Claudia Ester, Burkhard Luy, Holger Pu
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.27159

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators.

Autori: De Mol E, Szulc E, Di Sanza C, Martínez-Cristóbal P, Bertoncini CW, Fenwick RB, Frigolé-Vivas M, Masín M, Hunter I, Buzón V, Brun-Heath I, García J, De Fabritiis G, Estébanez-Perpiñá E, McEwan IJ, Nebreda ÁR, Salvatella X.
Pubblicato in: Structure, 2018, ISSN 0969-2126
Editore: Cell press

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Autori: Bahareh Eftekharzadeh, Alessandro Piai, Giulio Chiesa, Daniele Mungianu, Jesús García, Roberta Pierattelli, Isabella C. Felli, Xavier Salvatella
Pubblicato in: Biophysical journal, 2016, Pagina/e 2361-2366, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2016.04.022

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

Autori: Eva De Mol, R. Bryn Fenwick, Christopher T. W. Phang, Victor Buzón, Elzbieta Szulc, Alex de la Fuente, Albert Escobedo, Jesús García, Carlos W. Bertoncini, Eva Estébanez-Perpiñá, Iain J. McEwan, Antoni Riera, and Xavier Salvatella
Pubblicato in: ACS Chemical Biology, 2016, Pagina/e 2499-2505, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.6b00182