Next-generation in vivo models for improved pancreatic cancer therapies

Publications

In vivo functional screening for systems-level integrative cancer genomics

Auteurs: Julia Weber, Christian J. Braun, Dieter Saur, Roland Rad
Publié dans: Nature Reviews Cancer, Numéro 20/10, 2020, Page(s) 573-593, ISSN 1474-175X
Éditeur: Nature Publishing Group
DOI: 10.1038/s41568-020-0275-9

Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer

Auteurs: Maximilian Reichert, Basil Bakir, Leticia Moreira, Jason R. Pitarresi, Karin Feldmann, Lauren Simon, Kensuke Suzuki, Ravikanth Maddipati, Andrew D. Rhim, Anna M. Schlitter, Mark Kriegsmann, Wilko Weichert, Matthias Wirth, Kathleen Schuck, Günter Schneider, Dieter Saur, Albert B. Reynolds, Andres J. Klein-Szanto, Burcin Pehlivanoglu, Bahar Memis, N. Volkan Adsay, Anil K. Rustgi
Publié dans: Developmental Cell, Numéro 45/6, 2018, Page(s) 696-711.e8, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2018.05.025

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype

Auteurs: Alexander Biederstädt, Zonera Hassan, Christian Schneeweis, Markus Schick, Lara Schneider, Alexander Muckenhuber, Yingfen Hong, Gerrit Siegers, Lisa Nilsson, Matthias Wirth, Zahra Dantes, Katja Steiger, Kathrin Schunck, Steve Langston, H-P Lenhof, Andrea Coluccio, Felix Orben, Jolanta Slawska, Anna Scherger, Dieter Saur, Stefan Müller, Roland Rad, Wilko Weichert, Jonas Nilsson, Maximilian Reiche
Publié dans: Gut, Numéro 69/8, 2020, Page(s) 1472-1482, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317856

Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice

Auteurs: Mathias J Friedrich, Lena Rad, Iraad F Bronner, Alexander Strong, Wei Wang, Julia Weber, Matthew Mayho, Hannes Ponstingl, Thomas Engleitner, Carolyn Grove, Anja Pfaus, Dieter Saur, Juan Cadiñanos, Michael A Quail, George S Vassiliou, Pentao Liu, Allan Bradley, Roland Rad
Publié dans: Nature Protocols, Numéro 12/2, 2017, Page(s) 289-309, ISSN 1754-2189
Éditeur: Nature Publishing Group
DOI: 10.1038/nprot.2016.164

Analysis pipelines for cancer genome sequencing in mice

Auteurs: Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S. Vassiliou, Mathias J. Friedrich, Dieter Saur, Ignacio Varela, Roland Rad
Publié dans: Nature Protocols, Numéro 15/2, 2020, Page(s) 266-315, ISSN 1754-2189
Éditeur: Nature Publishing Group
DOI: 10.1038/s41596-019-0234-7

Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncology

Auteurs: Zahra Dantes, Hsi-Yu Yen, Nicole Pfarr, Christof Winter, Katja Steiger, Alexander Muckenhuber, Alexander Hennig, Sebastian Lange, Thomas Engleitner, Rupert Öllinger, Roman Maresch, Felix Orben, Irina Heid, Georgios Kaissis, Kuangyu Shi, Geoffrey Topping, Fabian Stögbauer, Matthias Wirth, Katja Peschke, Aristeidis Papargyriou, Massoud Rezaee-Oghazi, Karin Feldmann, Arlett P.G. Schäfer, Raphela R
Publié dans: JCI Insight, Numéro 5/15, 2020, ISSN 2379-3708
Éditeur: JCI
DOI: 10.1172/jci.insight.137809

Single cell polarity in liquid phase facilitates tumour metastasis

Auteurs: Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R.
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-03139-6

Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells

Auteurs: Lele Wang, Linlin Zhao, Guo Wei, Dieter Saur, Barbara Seidler, Junyan Wang, Chuanxin Wang, Tonggang Qi
Publié dans: Journal of Cellular Biochemistry, Numéro 119/8, 2018, Page(s) 6644-6656, ISSN 0730-2312
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jcb.26847

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Auteurs: Dietrich A. Ruess, Guus J. Heynen, Katrin J. Ciecielski, Jiaoyu Ai, Alexandra Berninger, Derya Kabacaoglu, Kivanc Görgülü, Zahra Dantes, Sonja M. Wörmann, Kalliope N. Diakopoulos, Angeliki F. Karpathaki, Marlena Kowalska, Ezgi Kaya-Aksoy, Liang Song, Eveline A. Zeeuw van der Laan, María P. López-Alberca, Marc Nazaré, Maximilian Reichert, Dieter Saur, Mert M. Erkan, Ulrich T. Hopt, Bruno Sai
Publié dans: Nature Medicine, Numéro 24/7, 2018, Page(s) 954-960, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-018-0024-8

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

Auteurs: Julia Weber, Rupert Öllinger, Mathias Friedrich, Ursula Ehmer, Maxim Barenboim, Katja Steiger, Irina Heid, Sebastian Mueller, Roman Maresch, Thomas Engleitner, Nina Gross, Ulf Geumann, Beiyuan Fu, Angela Segler, Detian Yuan, Sebastian Lange, Alexander Strong, Jorge de la Rosa, Irene Esposito, Pentao Liu, Juan Cadiñanos, George S. Vassiliou, Roland M. Schmid, Günter Schneider, Kristian Unger, Fe
Publié dans: Proceedings of the National Academy of Sciences, Numéro 112/45, 2015, Page(s) 13982-13987, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1512392112

RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait

Auteurs: Stephanie C. Koch, Marta Garcia Del Barrio, Antoine Dalet, Graziana Gatto, Thomas Günther, Jingming Zhang, Barbara Seidler, Dieter Saur, Roland Schüle, Martyn Goulding
Publié dans: Neuron, Numéro 96/6, 2017, Page(s) 1419-1431.e5, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2017.11.011

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer.

Auteurs: Chiara Falcomatà; Stefanie Bärthel; Angelika Ulrich; Sandra Diersch; Christian Veltkamp; Lena Rad; Fabio Boniolo; Myriam Solar; Katja Steiger; Barbara Seidler; Magdalena Zukowska; Joanna Madej; Mingsong Wang; Rupert Öllinger; Roman Maresch; Maxim Barenboim; Stefan Eser; Markus Tschurtschenthaler; Arianeb Mehrabi; Stephanie Roessler; Benjamin Goeppert; Alexander Kind; Angelika Schnieke; Maria S.
Publié dans: Cancer Discovery, Numéro 11, 2021, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-0209

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Auteurs: Felix Dietlein; Bastian Kalb; Mladen Jokic; Elisa M. Noll; Alexander Strong; Lars Tharun; Luka Ozretić; Helen Künstlinger; Kato Kambartel; Winfried Randerath; Christian Jüngst; Anna Schmitt; Alessandro Torgovnick; André Richters; Daniel Rauh; Florian Siedek; Thorsten Persigehl; Cornelia Mauch; Jirina Bartkova; Jirina Bartkova; Allan Bradley; Martin R. Sprick; Andreas Trumpp; Roland Rad; Dieter
Publié dans: Cell, Numéro 15, 2016, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2015.05.053

Differentiation potential of individual olfactory c-Kit+ progenitors determined via multicolor lineage tracing

Auteurs: Garrett M. Goss, Nirupa Chaudhari, Joshua M. Hare, Raphael Nwojo, Barbara Seidler, Dieter Saur, Bradley J. Goldstein
Publié dans: Developmental Neurobiology, Numéro 76/3, 2016, Page(s) 241-251, ISSN 1932-8451
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/dneu.22310

MTOR inhibitor-based combination therapies for pancreatic cancer

Auteurs: Zonera Hassan, Christian Schneeweis, Matthias Wirth, Christian Veltkamp, Zahra Dantes, Benedikt Feuerecker, Güralp O Ceyhan, Shirley K Knauer, Wilko Weichert, Roland M Schmid, Roland Stauber, Alexander Arlt, Oliver H Krämer, Roland Rad, Maximilian Reichert, Dieter Saur, Günter Schneider
Publié dans: British Journal of Cancer, Numéro 118/3, 2018, Page(s) 366-377, ISSN 0007-0920
Éditeur: Nature Publishing Group
DOI: 10.1038/bjc.2017.421

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting

Auteurs: Phyllis F. Cheung, Florian Neff, Christian Neander, Anna Bazarna, Konstantinos Savvatakis, Sven-Thorsten Liffers, Kristina Althoff, Chang-Lung Lee, Everett J. Moding, David G Kirsch, Dieter Saur, Alexandr V. Bazhin, Marija Trajkovic-Arsic, Mathias F. Heikenwalder, Jens T. Siveke
Publié dans: Cancer Research, Numéro 78/17, 2018, Page(s) 4997-5010, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-18-0052

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program

Auteurs: Yang Chen, Valerie S LeBleu, Julienne L Carstens, Hikaru Sugimoto, Xiaofeng Zheng, Shruti Malasi, Dieter Saur, Raghu Kalluri
Publié dans: EMBO Molecular Medicine, Numéro 10/10, 2018, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809085

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Auteurs: Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Len
Publié dans: Nature, Numéro 554/7690, 2018, Page(s) 62-68, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature25459

Tissue-specific tumorigenesis: context matters

Auteurs: Günter Schneider, Marc Schmidt-Supprian, Roland Rad, Dieter Saur
Publié dans: Nature Reviews Cancer, Numéro 17/4, 2017, Page(s) 239-253, ISSN 1474-175X
Éditeur: Nature Publishing Group
DOI: 10.1038/nrc.2017.5

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

Auteurs: Roman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich, Irina Heid, Katja Steiger, Julia Weber, Thomas Engleitner, Maxim Barenboim, Sabine Klein, Sandra Louzada, Ruby Banerjee, Alexander Strong, Teresa Stauber, Nina Gross, Ulf Geumann, Sebastian Lange, Marc Ringelhan, Ignacio Varela, Kristian Unger, Fengtang Yang, Roland M. Schmid, George S. Vassiliou, Rickmer Br
Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 10770, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms10770

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Auteurs: Falcomatà C, Bärthel S, Widholz SA, Schneeweis C, Montero JJ, Toska A, Mir J, Kaltenbacher T, Heetmeyer J, Swietlik JJ, Cheng JY, Teodorescu B, Reichert O, Schmitt C, Grabichler K, Coluccio A, Boniolo F, Veltkamp C, Zukowska M, Vargas AA, Paik WH, Jesinghaus M, Steiger K, Maresch R, Öllinger R, Ammon T, Baranov O, Robles MS, Rechenberger J, Kuster B, Meissner F, Reichert M, Flossdorf M, Rad R,
Publié dans: Nat Cancer, 2022, ISSN 1474-175X
Éditeur: Nature Publishing Group
DOI: 10.1038/s43018-021-00326-1

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body

Auteurs: Chenchen Pan, Oliver Schoppe, Arnaldo Parra-Damas, Ruiyao Cai, Mihail Ivilinov Todorov, Gabor Gondi, Bettina von Neubeck, Nuray Böğürcü-Seidel, Sascha Seidel, Katia Sleiman, Christian Veltkamp, Benjamin Förstera, Hongcheng Mai, Zhouyi Rong, Omelyan Trompak, Alireza Ghasemigharagoz, Madita Alice Reimer, Angel M. Cuesta, Javier Coronel, Irmela Jeremias, Dieter Saur, Amparo Acker-Palmer, Till Ac
Publié dans: Cell, Numéro 179/7, 2019, Page(s) 1661-1676.e19, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2019.11.013

Deciphering the universe of genetic context-dependencies using mouse models of cancer

Auteurs: Chiara Falcomatà, Stefanie Bärthel, Günter Schneider, Dieter Saur, Christian Veltkamp
Publié dans: Current Opinion in Genetics & Development, Numéro 54, 2019, Page(s) 97-104, ISSN 0959-437X
Éditeur: Elsevier BV
DOI: 10.1016/j.gde.2019.04.002

Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses

Auteurs: Sebastian Mueller, Sebastian Lange, Katharina A. N. Collins, Stefan Krebs, Helmut Blum, Günter Schneider, Lena Rad, Dieter Saur, Roland Rad
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-18095-3

Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

Auteurs: Benoît Thibault; Fernanda Ramos-Delgado; Elvire Pons-Tostivint; Nicole Therville; Célia Cintas; Silvia Arcucci; Stéphanie Cassant-Sourdy; Gabriela Reyes-Castellanos; Marie Tosolini; Amelie V. Villard; Coralie Cayron; Romain Baer; Justine Bertrand-Michel; Delphine Pagan; Dina Ferreira Da Mota; Hongkai Yan; Hongkai Yan; Chiara Falcomatà; Chiara Falcomatà; Fabrice Muscari; Barbara Bournet; Jean
Publié dans: EMBO Molecular Medicine, Numéro 15, 2021, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013502

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

Auteurs: Roland Rad, Lena Rad, Wei Wang, Alexander Strong, Hannes Ponstingl, Iraad F Bronner, Matthew Mayho, Katja Steiger, Julia Weber, Maren Hieber, Christian Veltkamp, Stefan Eser, Ulf Geumann, Rupert Öllinger, Magdalena Zukowska, Maxim Barenboim, Roman Maresch, Juan Cadiñanos, Mathias Friedrich, Ignacio Varela, Fernando Constantino-Casas, Aaron Sarver, Jelle ten Hoeve, Haydn Prosser, Barbara Seidler,
Publié dans: Nature Genetics, Numéro 47/1, 2015, Page(s) 47-56, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/ng.3164

Blocking the road to de‐differentiation: HNF 1A/ KDM 6A complex safeguards epithelial integrity in pancreatic cancer

Auteurs: Stefanie Bärthel, Günter Schneider, Dieter Saur
Publié dans: The EMBO Journal, Numéro 39/9, 2020, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.2020104759

Personalizing KRAS -Mutant Allele–Specific Therapies

Auteurs: Chiara Falcomatà, Günter Schneider, Dieter Saur
Publié dans: Cancer Discovery, Numéro 10/1, 2020, Page(s) 23-25, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-1261

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