Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders

Información del proyecto

UNEXPECTED

Identificador del acuerdo de subvención: 648894

DOI 10.3030/648894

Proyecto cerrado

Fecha de la firma de la CE 30 Julio 2015

Fecha de inicio 1 Agosto 2015

Fecha de finalización 31 Enero 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 000 000,00

Aportación de la UE € 2 000 000,00

Coordinado por

LUNDS UNIVERSITET
Sweden

Publicaciones

Peer reviewed articles (9)

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws

Autores: Ludwig Schmiderer, Agatheeswaran Subramaniam, Kristijonas Žemaitis, Alexandra Bäckström, David Yudovich, Svetlana Soboleva, Roman Galeev, Christelle N. Prinz, Jonas Larsson, Martin Hjort
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/35, 2020, Página(s) 21267-21273, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2001367117

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Autores: Agatheeswaran Subramaniam, Kristijonas Žemaitis, Mehrnaz Safaee Talkhoncheh, David Yudovich, Alexandra Bäckström, Shubhranshu Debnath, Jun Chen, Mayur Vilas Jain, Roman Galeev, Massimiliano Gaetani, Roman A. Zubarev, Jonas Larsson
Publicado en: Blood, Edición 136/19, 2020, Página(s) 2151-2161, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020005827

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Autores: Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet
Publicado en: Haematologica, Edición 103/9, 2018, Página(s) 1444-1450, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.188466

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

Autores: Justyna Rak, Katie Foster, Katarzyna Potrzebowska, Mehrnaz Safaee Talkhoncheh, Natsumi Miharada, Karolina Komorowska, Therese Torngren, Anders Kvist, Åke Borg, Lena Svensson, Dominique Bonnet, Jonas Larsson
Publicado en: Blood, Edición 129/8, 2017, Página(s) 950-958, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2016-06-720649

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

Autores: Roman Galeev, Aurélie Baudet, Praveen Kumar, Alexandra Rundberg Nilsson, Björn Nilsson, Shamit Soneji, Therese Törngren, Åke Borg, Anders Kvist, Jonas Larsson
Publicado en: Cell Reports, Edición 14/12, 2016, Página(s) 2988-3000, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.02.082

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

Autores: Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås
Publicado en: Haematologica, Edición 104/10, 2019, Página(s) 2006-2016, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.192062

HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

Autores: Praveen Kumar, Dominik Beck, Roman Galeev, Julie A. I. Thoms, Mehrnaz Safaee Talkhoncheh, Ineke de Jong, Ashwin Unnikrishnan, Aurélie Baudet, Agatheeswaran Subramaniam, John E. Pimanda, Jonas Larsson
Publicado en: Blood Advances, Edición 3/4, 2019, Página(s) 681-691, ISSN 2473-9529
Editor: The American Society of Hematology
DOI: 10.1182/bloodadvances.2018023986

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

Autores: Agatheeswaran Subramaniam, Mehrnaz Safaee Talkhoncheh, Mattias Magnusson, Jonas Larsson
Publicado en: Haematologica, Edición 104/2, 2019, Página(s) e47-e50, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.198515

Combined lentiviral- and RNA-mediated CRISPR/Cas9 delivery for efficient and traceable gene editing in human hematopoietic stem and progenitor cells

Autores: David Yudovich, Alexandra Bäckström, Ludwig Schmiderer, Kristijonas Žemaitis, Agatheeswaran Subramaniam, Jonas Larsson
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-79724-x