Novel neurophysiological techniques to quantify pain and stratify patients

Project Information

PAINSTRAT

Grant agreement ID: 649020

DOI 10.3030/649020

Project closed

EC signature date 27 August 2015

Start date 1 January 2016

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 627 825,00

EU contribution € 1 627 825,00

Coordinated by

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

Publications

Peer reviewed articles (44)

Spatial Patterns of Brain Activity Preferentially Reflecting Transient Pain and Stimulus Intensity

Author(s): M Liang, Q Su , A Mouraux , G D Iannetti
Published in: Cereb Cortex, 2019, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz026

Movement of environmental threats modifies the relevance of the defensive eye-blink in a spatially-tuned manner

Author(s): Somervail, R.; Bufacchi, R. J.; Guo, Y.; Kilintari, M.; Novembre, G.;Swapp, D.;Steed, A.;Iannetti, G. D.;
Published in: Scientific Reports, Issue 9, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-40075-x

A novel method to selectively elicit cold sensations without touch

Author(s): Ivan Ezquerra-Romano 1, Maansib Chowdhury 2, Caterina Maria Leone 3, Gian Domenico Iannetti 4, Patrick Haggard
Published in: Journal of Neuroscience Methods, Issue volume 385, 2022, Page(s) page 109,763, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2022.109763

Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience

Author(s): Hailu Wang 1 2, Yifei Guo 3 4, Yiheng Tu 1 2, Weiwei Peng 5, Xuejing Lu 1 2, Yanzhi Bi 1 2, Gian Domenico Iannetti 3 4, Li Hu 1 2
Published in: Cerebral Cortex, 2022, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhac090

The effect of salient stimuli on neural oscillations, isometric force, and their coupling

Author(s): Giacomo Novembre, Vijay M. Pawar, Marina Kilintari, Rory J. Bufacchi, Yifei Guo, John C. Rothwell and Gian Domenico Iannetti
Published in: neuroimage, Issue 2019 Sep;198, 2019, Page(s) 221-230, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.05.032

Feedforward and feedback pathways of nociceptive and tactile processing in human somatosensory system: A study of dynamic causal modeling of fMRI data

Author(s): Yingchao Song; Qian Su;Qingqing Yang;Rui Zhao;Guotao Yin;Wen Qin;Gian Domenico Iannetti; Chunshui Yu;Meng Liang;
Published in: NeuroImage, Issue volume 234, 2021, ISSN 1095-9572
Publisher: Elsevier
DOI: 10.1016/j.neuroimage.2021.117957

The Value of Actions, in Time and Space

Author(s): R.J. Bufacchi; Gian Domenico Iannetti;
Published in: Trends in Cognitive Sciences, Issue 23, 2019, Page(s) 270-271, ISSN 1364-6613
Publisher: Elsevier BV
DOI: 10.1016/j.tics.2019.01.011

Ultralow-frequency neural entrainment to pain

Author(s): Yifei Guo 1 2, Rory John Bufacchi 1 2, Giacomo Novembre 1 2, Marina Kilintari 2, Massieh Moayedi 3, Li Hu 4 5, Gian Domenico Iannetti 1 2
Published in: Plos Biology, Issue 18, 2020, ISSN 1545-7885
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3000491

No temporal contrast enhancement of simple decreases in noxious heat

Author(s): Brianna Beck, Sahana Gnanasampanthan , Gian Domenico Iannetti , Patrick Haggard
Published in: Journal of Neurophysiology, 2019, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00335.2018

The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations

Author(s): Lupeng Yue; Gian Domenico Iannetti;Li Hu;
Published in: The Journal of Neuroscience, Issue 40, 2020, Page(s) 3,478-3,490, ISSN 1529-2401
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.0255-20.2020

Brain regions preferentially responding to transient and iso-intense painful or tactile stimuli

Author(s): Q Su 1, W Qin 2, Q Q Yang 1, C S Yu 3, T Y Qian 4, A Mouraux 5, G D Iannetti 6, M Liang 7
Published in: NeuroImage, Issue May 1;29(5), 2019, Page(s) 2211-2227, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.01.039

Alpha and gamma oscillation amplitudes synergistically predict the perception of forthcoming nociceptive stimuli

Author(s): Yiheng Tu 1 2, Zhiguo Zhang 2 3 4, Ao Tan 2, Weiwei Peng 1, Yeung Sam Hung 2, Massieh Moayedi 5, Gian Domenico Iannetti 5, Li Hu 1 5
Published in: Hum Brain Mapp, Issue 37(2), 2016, Page(s) 501-14, ISSN 1065-9471
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hbm.23048

Fetal pain and its relevance to abortion policy

Author(s): T. V. Salomons & G. D. Iannetti
Published in: Nature, Issue 2022, 2022, Page(s) 1396–1398, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-022-01188-1

An Action Field Theory of Peripersonal Space

Author(s): Rory J Bufacchi , Gian Domenico Iannetti
Published in: Trends in Cognitive Sciences, Issue Dec;22(12), 2018, Page(s) 1076-1090, ISSN 1364-6613
Publisher: Elsevier BV
DOI: 10.1016/j.tics.2018.09.004

Egocentric value maps of the near-body environment

Author(s): Rory John Bufacchi, Richard Somervail, Aoife Maria Fitzpatrick, Roberto Caminiti, Gian Domenico Iannetti
Published in: Cold Spring Harbor Laboratory, 2023, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/2022.08.18.504456

Fine-grained mapping of cortical somatotopies in chronic Complex Regional Pain Syndrome

Author(s): Flavia Mancini 1 2, Audrey P Wang 3 4, Mark M Schira 3 5, Zoey J Isherwood 5, James H McAuley 3 6, Giandomenico D Iannetti 2 7, Martin I Sereno 8 9, G Lorimer Moseley 3 10, Caroline D Rae 3 6
Published in: Journal of Neuroscience, Issue 2019 Nov 13;39(46), 2019, Page(s) 9185-9196, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2005-18.2019

Rethinking blinking: No cognitive modulation of reflex eye protection in early onset blindness

Author(s): S B Wallwork 1, R J Bufacchi 2, G L Moseley 3, G D Iannetti 4
Published in: Clin Neurophysiol, 2018, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp275715

Rethinking blinking: No cognitive modulation of reflex eye protection in early onset blindness

Author(s): S B Wallwork 1, R J Bufacchi 2, G L Moseley 3, G D Iannetti 4
Published in: Clinical Neurophysiology, Issue volume 128, 2017, Page(s) pages 16-17, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2016.10.089

Muscular effort increases hand-blink reflex magnitude

Author(s): R J Bufacchi 1, S Ponticelli 2, G Novembre 3, M Kilintari 2, Y Guo 2, G D Iannetti 4
Published in: Neuroscience Letters, Issue May 29;702, 2019, Page(s) 11-14, ISSN 0304-3940
Publisher: Elsevier BV
DOI: 10.1016/j.neulet.2018.11.046

Neurobiological mechanisms of TENS-induced analgesia

Author(s): W W Peng , Z Y Tang , F R Zhang , H Li , Y Z Kong , G D Iannetti , L Hu
Published in: NeuroImage, Issue Jul 15;195, 2019, Page(s) 396-408, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.03.077

Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats

Author(s): R Somervail 1 2, F Zhang 3 4, G Novembre 2, R J Bufacchi 2, Y Guo 2, M Crepaldi 5, L Hu 3 4, G D Iannetti 1 2
Published in: Cerebral Cortex, Issue volume 31, issue 2, 2021, Page(s) 949-960, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhaa267

Brain oscillations reflecting pain-related behavior in freely moving rats

Author(s): Weiwei Peng, Xiaolei Xia, Ming Yi, Gan Huang, Zhiguo Zhang, Giandomenico Iannetti, Li Hu
Published in: PAIN, Issue 159/1, 2018, Page(s) 106-118, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000001069

Pain outside the body: defensive peripersonal space deformation in trigeminal neuralgia

Author(s): R. J. Bufacchi, C. F. Sambo, G. Di Stefano, G. Cruccu, G. D. Iannetti
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-12466-5

Pain in the ACC?

Author(s): Tor D. Wager, Lauren Y. Atlas, Matthew M. Botvinick, Luke J. Chang, Robert C. Coghill, Karen Deborah Davis, Gian Domenico Iannetti, Russell A. Poldrack, Alexander J. Shackman, Tal Yarkoni
Published in: Proceedings of the National Academy of Sciences, Issue 113/18, 2016, Page(s) E2474-E2475, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1600282113

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

Author(s): Karen D. Davis, Herta Flor, Henry T. Greely, Gian Domenico Iannetti, Sean Mackey, Markus Ploner, Amanda Pustilnik, Irene Tracey, Rolf-Detlef Treede, Tor D. Wager
Published in: Nature Reviews Neurology, Issue 13/10, 2017, Page(s) 624-638, ISSN 1759-4758
Publisher: Nature Publishing Group
DOI: 10.1038/nrneurol.2017.122

The search for pain biomarkers in the human brain

Author(s): André Mouraux, Gian Domenico Iannetti
Published in: Brain, Issue 141/12, 2018, Page(s) 3290-3307, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awy281

Temporal Profile and Limb-specificity of Phasic Pain-Evoked Changes in Motor Excitability

Author(s): M. Algoet, J. Duque, G.D. Iannetti, A. Mouraux
Published in: Neuroscience, Issue 386, 2018, Page(s) 240-255, ISSN 0306-4522
Publisher: Elsevier BV
DOI: 10.1016/j.neuroscience.2018.06.039

Characterizing the Short-Term Habituation of Event-Related Evoked Potentials

Author(s): Flavia Mancini, Alessia Pepe, Alberto Bernacchia, Giulia Di Stefano, André Mouraux, Gian Domenico Iannetti
Published in: eneuro, Issue 5/5, 2018, Page(s) ENEURO.0014-18.2018, ISSN 2373-2822
Publisher: Society for Neuroscience
DOI: 10.1523/ENEURO.0014-18.2018

Saliency Detection as a Reactive Process: Unexpected Sensory Events Evoke Corticomuscular Coupling

Author(s): Giacomo Novembre, Vijay M. Pawar, Rory J. Bufacchi, Marina Kilintari, Mandayam Srinivasan, John C. Rothwell, Patrick Haggard, Gian Domenico Iannetti
Published in: The Journal of Neuroscience, Issue 38/9, 2018, Page(s) 2385-2397, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.2474-17.2017

Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents

Author(s): Q.Q. Jin, G.Q. Wu, W.W. Peng, X.L. Xia, L. Hu, G.D. Iannetti
Published in: The Journal of Neuroscience, Issue 38/24, 2018, Page(s) 5538-5550, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.3654-17.2018

Ineffectiveness of tactile gating shows cortical basis of nociceptive signaling in the Thermal Grill Illusion

Author(s): E. R. Ferrè, G. D. Iannetti, J. A. van Dijk, P. Haggard
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24635-1

Painful Issues in Pain Prediction

Author(s): Li Hu, Gian Domenico Iannetti
Published in: Trends in Neurosciences, Issue 39/4, 2016, Page(s) 212-220, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2016.01.004

Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates

Author(s): M. Moayedi, G. Di Stefano, M. T. Stubbs, B. Djeugam, M. Liang, G. D. Iannetti
Published in: eNeuro, Issue 3/3, 2016, ISSN 2373-2822
Publisher: Society for Neuroscience
DOI: 10.1523/ENEURO.0151-15.2016

Perceptual learning to discriminate the intensity and spatial location of nociceptive stimuli

Author(s): Flavia Mancini, Karina Dolgevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D. Iannetti
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep39104

Gravitational cues modulate the shape of defensive peripersonal space

Author(s): Rory John Bufacchi, Gian Domenico Iannetti
Published in: Current Biology, Issue 26/21, 2016, Page(s) R1133-R1134, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2016.09.025

The “Pain Matrix” in Pain-Free Individuals

Author(s): Tim V. Salomons, Gian Domenico Iannetti, Meng Liang, John N. Wood
Published in: JAMA Neurology, Issue 73/6, 2016, Page(s) 755, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2016.0653

Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways

Author(s): M. Liang, M. C. Lee, J. O'Neill, A. H. Dickenson, G. D. Iannetti
Published in: Journal of Neurophysiology, Issue 116/2, 2016, Page(s) 286-295, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00013.2016

Limits of decoding mental states with fMRI

Author(s): Rami Jabakhanji 1, Andrew D Vigotsky 2, Jannis Bielefeld 1, Lejian Huang 1, Marwan N Baliki 3, Giandomenico Iannetti 4, A Vania Apkarian 5
Published in: Cortex, Issue volume 149, 2022, Page(s) pages 101-122, ISSN 0010-9452
Publisher: Masson Publishing
DOI: 10.1016/j.cortex.2021.12.015

The blink reflex magnitude is continuously adjusted according to both current and predicted stimulus position with respect to the face

Author(s): Wallwork, Sarah B.;Talbot, Kerwin; Camfferman, Danny;Moseley, G.L.;Iannetti, G.D
Published in: Cortex, 2016, ISSN 0010-9452
Publisher: Masson Publishing
DOI: 10.1016/j.cortex.2016.04.009

Brain Responses to Surprising Stimulus Offsets: Phenomenology and Functional Significance

Author(s): R Somervail 1 2, R J Bufacchi 1, C Salvatori 1, L Neary-Zajiczek 3, Y Guo 1, G Novembre 1, G D Iannetti 1 2
Published in: Cerebral Cortex, Issue volume 32, 2022, Page(s) 2,231-2,244, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhab352

Local spatial analysis: an easy-to-use adaptive spatial EEG filter

Author(s): R.J. Bufacchi;Cesare Magri;Giacomo Novembre;Gian Domenico Iannetti
Published in: Journal of Neurophysiology, Issue volume 125, issue 2, 2021, Page(s) 509-521, ISSN 1522-1598
Publisher: American Physiological Society
DOI: 10.1152/jn.00560.2019

Hyperscanning Alone Cannot Prove Causality. Multibrain Stimulation Can

Author(s): Giacomo Novembre;Gian Domenico Iannetti;
Published in: Trends in Cognitive Sciences, Issue volume 25, issue 2, 2021, Page(s) pages 96-99, ISSN 1364-6613
Publisher: Elsevier BV
DOI: 10.1016/j.tics.2020.11.003

Neural indicators of perceptual variability of pain across species

Author(s): L Hu , G D Iannetti
Published in: Proceedings of the National Academy of Sciences, 2019, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1812499116

Towards a unified neural mechanism for reactive adaptive behaviour

Author(s): Giacomo Novembre;Gian Domenico Iannetti;
Published in: Progress in Neurobiology, Issue volume 204, 2021, Page(s) page 102,115, ISSN 0301-0082
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2021.102115