Periodic Reporting for period 1 - Oncoworm (ONCOWORM: Using functional genomics in highly regenerative flatworms to find novel cancer genes)
Période du rapport: 2016-04-05 au 2018-04-04
The overall objectives were
i) Provide new insights into the regulation of stem cell biology in planarians,
ii) Leverage of the planarian model to find new genes involved in human cancer,
iii) Direct transfer of this new knowledge to mammalian systems.
The output of this project will now integrate the planarian system with current mammalian cell based approaches to studying cancer.
In particular we found new genes that control stem cell proliferation in planarians, that have human counterparts that currently have no function assigned to them. These genes now represent important genes to study further, perhaps in mammalian systems.