GlucoCEST Imaging of Neoplastic Tumours

Deliverables

Development and implementation of optimized MR T2 and T1ρ techniques
Development and implementation of optimized MRI CEST sequences based, e.g. on SSFP
Optimised saturation and excitation RF pulses for 3T, 7T, and 9.4T
N-pool Bloch-McConnell simulation software

Estimate of the coefficients of variation, signal- and contrast-to-noise of both sequences on volunteers
Assessment of in vitro magnetic field dependence properties
Evaluation of response to new anticancer therapy
Assessment of intracellular energy substrate levels upon native and methylated glucose injections
Comparison of GlucoCEST contrast with [18F]FDG uptake
Report on maintenance of website, updating with project news, results, success information
Dependence of detection thresholds on administration ways
Combined optical and MR-based measurements of intracellular glucose concentration
Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Submission to the EC of Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Assessing the intra-/extracellular localisation of 3OMG by measuring pH

OMG by measuring pH

Ethical approval for animal experiments, with personal licenses (incl. translation)

Demonstration of obtaining ethical approval for animal experiments, with personal licenses (incl. translation) to ensure ethical requirements are met.

Technical validation of the GlucoCEST technique in human cancers
Biological validation of the GlucoCEST technique against imaging markers, histopathology and genomics
pK by combined CEST / 13C NMR spectroscopy
Development and testing of new Glucose analogues
Evaluation of response to conventional therapy
Ethics for scanning children and scanning of first paediatric lymphoma patient
Assessment of in vivo pH dependence of GlucoCEST contrast in mouse tumour models using CEST-based agents
Assessment of GlucoCEST effect of 3OMG on a number of tumour models including from breast tumour cell lines DA3, 4T1, and MCF7 and brain metastases of the DA3 tumour cells.

Scanning of 1st adult patient for head-and-neck tumours and gliomas
Up-to-date steady-state and dynamic MRI sequences for GlucoCEST

Set up of website

Set up of website to promote GLINT

Biomarker qualification of GlucoCEST

Publications

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments

Author(s): Moritz Zaiss, Goran Angelovski, Eleni Demetriou, Michael T. McMahon, Xavier Golay, Klaus Scheffler
Published in: Magnetic Resonance in Medicine, Issue 79/3, 2018, Page(s) 1708-1721, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26813

Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer

Author(s): Ferrauto, Giuseppe; Di Gregorio, Enza; Lanzardo, Stefania; Ciolli, Laura; Iezzi, Manuela; Aime, Silvio
Published in: Scientific Reports, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-28926-5

EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging

Author(s): Longo, Dario Livio; Moustaghfir, Fatima Zzahra; Zerbo, Alexandre; Consolino, Lorena; Anemone, Annasofia; Bracesco, Martina; Aime, Silvio
Published in: International Journal of Pharmaceutics, 2017, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2017.04.040

Snapshot-CEST: Optimizing spiral-centric-reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

Author(s): Moritz Zaiss, Philipp Ehses, Klaus Scheffler
Published in: NMR in Biomedicine, Issue 31/4, 2018, Page(s) e3879, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3879

3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T

Author(s): Anagha Deshmane, Moritz Zaiss, Tobias Lindig, Kai Herz, Mark Schuppert, Chirayu Gandhi, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Published in: Magnetic Resonance in Medicine, Issue 81/4, 2019, Page(s) 2412-2423, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27569

Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

Author(s): Francesca Arena, Pietro Irrera, Lorena Consolino, Sonia Colombo Serra, Moritz Zaiss, Dario Livio Longo
Published in: Journal of Magnetic Resonance, Issue 287, 2018, Page(s) 1-9, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2017.12.007

CEST imaging at 9.4 T using adjusted adiabatic spin-lock pulses for on- and off-resonant T1⍴-dominated Z-spectrum acquisition

Author(s): Kai Herz, Chirayu Gandhi, Mark Schuppert, Anagha Deshmane, Klaus Scheffler, Moritz Zaiss
Published in: Magnetic Resonance in Medicine, Issue 81/1, 2019, Page(s) 275-290, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27380

Possible artifacts in dynamic CEST MRI due to motion and field alterations

Author(s): Moritz Zaiss, Kai Herz, Anagha Deshmane, Mina Kim, Xavier Golay, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Published in: Journal of Magnetic Resonance, Issue 298, 2019, Page(s) 16-22, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2018.11.002

Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T

Author(s): Moritz Zaiss, Mark Schuppert, Anagha Deshmane, Kai Herz, Philipp Ehses, Lars Füllbier, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Published in: NeuroImage, Issue 179, 2018, Page(s) 144-155, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.026

3-O-Methyl-d-glucose mutarotation and proton exchange rates assessed by 13C, 1H NMR and by chemical exchange saturation transfer and spin lock measurements

Author(s): Michal Rivlin, Gil Navon
Published in: Journal of Biomolecular NMR, Issue 72/1-2, 2018, Page(s) 93-103, ISSN 0925-2738
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0209-y

Adaptive denoising for chemical exchange saturation transfer MR imaging

Author(s): Johannes Breitling, Anagha Deshmane, Steffen Goerke, Andreas Korzowski, Kai Herz, Mark E. Ladd, Klaus Scheffler, Peter Bachert, Moritz Zaiss
Published in: NMR in Biomedicine, Issue 32/11, 2019, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4133

Multiple interleaved mode saturation (MIMOSA) for B 1 + inhomogeneity mitigation in chemical exchange saturation transfer

Author(s): Andrzej Liebert, Moritz Zaiss, Rene Gumbrecht, Katharina Tkotz, Peter Linz, Benjamin Schmitt, Frederik B. Laun, Arnd Doerfler, Michael Uder, Armin M. Nagel
Published in: Magnetic Resonance in Medicine, Issue 82/2, 2019, Page(s) 693-705, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27762

Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla

Author(s): Moritz Zaiss, Annasofia Anemone, Steffen Goerke, Dario Livio Longo, Kai Herz, Rolf Pohmann, Silvio Aime, Michal Rivlin, Gil Navon, Xavier Golay, Klaus Scheffler
Published in: NMR in Biomedicine, 2019, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4113

Molecular imaging of tumors by chemical exchange saturation transfer MRI of glucose analogs

Author(s): Michal Rivlin, Gil Navon
Published in: Quantitative Imaging in Medicine and Surgery, Issue 9/10, 2019, Page(s) 1731-1746, ISSN 2223-4292
Publisher: AME Publishing company
DOI: 10.21037/qims.2019.09.12

Challenges in glucoCEST MR body imaging at 3 Tesla

Author(s): Mina Kim, Francisco Torrealdea, Sola Adeleke, Marilena Rega, Vincent Evans, Teresita Beeston, Katerina Soteriou, Stefanie Thust, Aaron Kujawa, Sachi Okuchi, Elizabeth Isaac, Wivijin Piga, Jonathan R. Lambert, Asim Afaq, Eleni Demetriou, Pratik Choudhary, King Kenneth Cheung, Sarita Naik, David Atkinson, Shonit Punwani, Xavier Golay
Published in: Quantitative Imaging in Medicine and Surgery, Issue 9/10, 2019, Page(s) 1628-1640, ISSN 2223-4292
Publisher: AME Publishing Company
DOI: 10.21037/qims.2019.10.05

Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging

Author(s): Aaron Kujawa, Mina Kim, Eleni Demetriou, Annasofia Anemone, Dario Livio Longo, Moritz Zaiss, Xavier Golay
Published in: Journal of Magnetic Resonance, Issue 300, 2019, Page(s) 120-134, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2019.01.006

CEST MRI of 3-O-methyl-D-glucose on different breast cancer models

Author(s): Michal Rivlin, Gil Navon
Published in: Magnetic Resonance in Medicine, 2017, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26752

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

Author(s): Annasofia Anemone, Lorena Consolino, Laura Conti, Francesca Reineri, Federica Cavallo, Silvio Aime, Dario Longo
Published in: International Journal of Oncology, 2017, ISSN 1019-6439
Publisher: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4029

Principal Process Analysis of dynamic GlucoCEST MRI data

Author(s): Casagranda, Stefano; Pizzolato, Marco; Torrealdea, Francisco; Golay, Xavier; Boutelier, Timothé
Published in: ISMRM 2018, Issue 1, 2018
Publisher: Archives ouvertes HAL

Bayesian fitting of Chemical Exchange Saturation Transfer (CEST) imaging data with an analytical model for multiple CEST pools

Author(s): Aaron Kujawa , Eleni Demetriou , Mina Kim , Moritz Zaiss , Xavier Golay
Published in: ISMRM 2019, 2019
Publisher: International Society for Magnetic Resonance in Medicine

Fluid suppression in CEST imaging affects predominantly IDH-mutant 1p/19q retained gliomas with T2-FLAIR mismatch

Author(s): S. Casagranda, L. Mancini, G. Gautier, P. Peter, B. Lopez, S. Brandner, E. De Vita, X. Golay, and S. Bisdas
Published in: ISMRM 2020, 2020
Publisher: International Society for Magnetic Resonance in Medicine

Glioma staging with CEST asymmetry curves and amides/amines ratio

Author(s): L.Mancini, S. Casagranda, F. Torrealdea, M.Rega, E. De Vita, B. Lopez, S. Brandner, B. Schmitt, P. Liebig, E. Sanverdi, X. Golay, S. Bisdas
Published in: ISRM 2020, 2020
Publisher: International Society for Magnetic Resonance in Medicine

Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner

Author(s): Mina Kim , Marco Battiston , Eleni Demetriou , Aaron Kujawa , Torben Schneider , Vincent Evans , Sachi Okuchi , David Atkinson , Claudia Wheeler-Kingshott , Xavier Golay
Published in: ISMRM 2019, 2019
Publisher: International Society for Magnetic Resonance in Medicine

T1ρ‐based dynamic glucose‐enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain

Author(s): Kai Herz, Tobias Lindig, Anagha Deshmane, Jens Schittenhelm, Marco Skardelly, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler, Moritz Zaiss
Published in: Magnetic Resonance in Medicine, Issue 82/5, 2019, Page(s) 1832-1847, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27857

Intellectual Property Rights

GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES

Application/Publication number: EP 15732449
Date: 2015-03-26

METHOD AND APPARATUS FOR PROCESSING MAGNETIC RESONANCE DATA USING MACHINE LEARNING

Application/Publication number: 18 191698
Date: 2018-08-30

Methods and means for imaging

Application/Publication number: GB 1705653.2
Date: 2017-04-07

GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES

Application/Publication number: EP 15732449
Date: 2015-03-26

Methods and means for imaging

Application/Publication number: GB 1705653.2
Date: 2017-04-07

GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES

Application/Publication number: EP 15732449
Date: 2015-03-26

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Deliverables

Publications

Intellectual Property Rights

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