Design and redesign of a plant immune receptor complex

Project Information

ImmunityByPairDesign

Grant agreement ID: 669926

DOI 10.3030/669926

Project closed

EC signature date 30 September 2015

Start date 1 October 2015

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 978,00

EU contribution € 2 499 978,00

Coordinated by

THE SAINSBURY LABORATORY
United Kingdom

Publications

Peer reviewed articles (19)

Mutual potentiation of plant immunity by cell-surface and intracellular receptors

Author(s): Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding, Jonathan D G Jones
Published in: Nature, Issue 592(7852), 2021, Page(s) 110-115, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03315-7

Autoactive Arabidopsis RPS4 alleles require partner protein RRS1-R

Author(s): Hailong Guo, Shanshan Wang, Jonathan D G Jones
Published in: Plant Physiology, Issue 185/3, 2021, Page(s) 761-764, ISSN 0032-0889
Publisher: American Society of Plant Biologists
DOI: 10.1093/plphys/kiaa076

Plant NLRs get by with a little help from their friends

Author(s): Joanna M Feehan, Baptiste Castel, Adam R Bentham, Jonathan D G Jones
Published in: Current Opinion in Plant Biology, Issue 56, 2020, Page(s) 99-108, ISSN 1435-8603
Publisher: Georg Thieme Verlag
DOI: 10.1016/j.pbi.2020.04.006

Exploring folds, evolution and host interactions: understanding effector structure/function in disease and immunity

Author(s): Nitika Mukhi, Danylo Gorenkin, Mark J. Banfield
Published in: New Phytologist, Issue 2, 2020, Page(s) 326-333, ISSN 0028-646X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nph.16563

Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities

Author(s): Baptiste Castel, Sebastian Fairhead, Oliver J Furzer, Amey Redkar, Shanshan Wang, Volkan Cevik, Eric B Holub, Jonathan D G Jones
Published in: The Plant Journal, Issue 107, 2021, Page(s) 1490-1502, ISSN 0960-7412
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tpj.15396

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants

Author(s): Zane Duxbury, Shanshan Wang, Craig I MacKenzie, Jeannette L Tenthorey, Xiaoxiao Zhang, Sung Un Huh, Lanxi Hu, Lionel Hill, Pok Man Ngou, Pingtao Ding, Jian Chen, Yan Ma, Hailong Guo, Baptiste Castel, Panagiotis N Moschou, Maud Bernoux, Peter N Dodds, Russell E Vance, Jonathan D G Jones
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 117(31), 2020, Page(s) 18832-18839, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2001185117

Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor

Author(s): Nitika Mukhi, Hannah Brown, Danylo Gorenkin, Pingtao Ding, Adam R Bentham, Clare E M Stevenson, Jonathan D G Jones, Mark J Banfield
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 118(50), 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2113996118

Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity

Author(s): Xinhua Sun, Dmitry Lapin, Joanna M Feehan, Sara C Stolze, Katharina Kramer, Joram A Dongus, Jakub Rzemieniewski, Servane Blanvillain-Baufumé, Anne Harzen, Jaqueline Bautor, Paul Derbyshire, Frank L H Menke, Iris Finkemeier, Hirofumi Nakagami, Jonathan D G Jones, Jane E Parker
Published in: Nature Communications, Issue Jun 7;12(1), 2021, Page(s) 3335, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23614-x

A molecular roadmap to the plant immune system

Author(s): Adam R Bentham, Juan Carlos De la Concepcion, Nitika Mukhi, Rafał Zdrzałek, Markus Draeger, Danylo Gorenkin, Richard K Hughes, Mark J Banfield
Published in: Journal of Biological Chemistry, Issue 295(44), 2020, Page(s) 14916-14935, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.rev120.010852

Two-faced TIRs trip the immune switch

Author(s): Jonathan D. G. Jones, Mark J. Banfield
Published in: Proceedings of the National Academy of Sciences, Issue 114/10, 2017, Page(s) 2445-2446, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1700954114

The highly buffered Arabidopsis immune signaling network conceals the functions of its components

Author(s): Rachel A. Hillmer, Kenichi Tsuda, Ghanasyam Rallapalli, Shuta Asai, William Truman, Matthew D. Papke, Hitoshi Sakakibara, Jonathan D. G. Jones, Chad L. Myers, Fumiaki Katagiri
Published in: PLOS Genetics, Issue 13/5, 2017, Page(s) e1006639, ISSN 1553-7404
Publisher: PLOS
DOI: 10.1371/journal.pgen.1006639

Pathogen perception by NLRs in plants and animals: Parallel worlds

Author(s): Zane Duxbury, Yan Ma, Oliver J. Furzer, Sung Un Huh, Volkan Cevik, Jonathan D.G. Jones, Panagiotis F. Sarris
Published in: BioEssays, Issue 38/8, 2016, Page(s) 769-781, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201600046

Foundational and Translational Research Opportunities to Improve Plant Health

Author(s): Richard Michelmore, Gitta Coaker, Rebecca Bart, Gwyn Beattie, Andrew Bent, Toby Bruce, Duncan Cameron, Jeffery Dangl, Savithramma Dinesh-Kumar, Rob Edwards, Sebastian Eves-van den Akker, Walter Gassmann, Jean T. Greenberg, Linda Hanley-Bowdoin, Richard J. Harrison, Jagger Harvey, Ping He, Alisa Huffaker, Scot Hulbert, Roger Innes, Jonathan D. G. Jones, Isgouhi Kaloshian, Sophien Kamoun, Fumiaki Ka
Published in: Molecular Plant-Microbe Interactions, Issue 30/7, 2017, Page(s) 515-516, ISSN 0894-0282
Publisher: American Phytopathological Society
DOI: 10.1094/MPMI-01-17-0010-CR

Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors

Author(s): Yan Ma, Hailong Guo, Lanxi Hu, Paula Pons Martinez, Panagiotis N. Moschou, Volkan Cevik, Pingtao Ding, Zane Duxbury, Panagiotis F. Sarris, and Jonathan D. G. Jones
Published in: PNAS, Issue 41, 2018, Page(s) 10218-10227, ISSN 1091-6490
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.1811858115

A pentangular plant inflammasome

Author(s): Jeffery L. Dangl, Jonathan D. G. Jones
Published in: Science, Issue 364/6435, 2019, Page(s) 31-32, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax0174

Protein-protein interactions in the RPS4/RRS1 immune receptor complex

Author(s): Sung Un Huh, Volkan Cevik, Pingtao Ding, Zane Duxbury, Yan Ma, Laurence Tomlinson, Panagiotis F. Sarris, Jonathan D. G. Jones
Published in: PLOS Pathogens, Issue 13/5, 2017, Page(s) e1006376, ISSN 1553-7374
Publisher: PubMed.gov
DOI: 10.1371/journal.ppat.1006376

Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms

Author(s): Hailong Guo, Hee-Kyung Ahn, Jan Sklenar, Jianhua Huang, Yan Ma, Pingtao Ding, Frank L.H. Menke, Jonathan D.G. Jones
Published in: Cell Host & Microbe, Issue 27/5, 2020, Page(s) 769-781.e6, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.03.008

Diverse NLR immune receptors activate defence via the RPW 8‐ NLR NRG 1

Author(s): Baptiste Castel, Pok‐Man Ngou, Volkan Cevik, Amey Redkar, Dae‐Sung Kim, Ying Yang, Pingtao Ding, Jonathan D. G. Jones
Published in: New Phytologist, Issue 222/2, 2019, Page(s) 966-980, ISSN 0028-646X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nph.15659

Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity

Author(s): Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding, Amey Redkar, Hannah Brown, Yan Ma, Mark Youles, Laurence Tomlinson, Jonathan D G Jones
Published in: Journal of Experimental Botany, Issue 71/6, 2020, Page(s) 2186-2197, ISSN 0022-0957
Publisher: Oxford University Press
DOI: 10.1093/jxb/erz571