The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases

Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

Auteurs: R. Bordeira-Carriço, J. Teixeira, M. Duque, M. Galhardo, D. Ribeiro, R. Dominguez-Acemel, P. N. Firbas, J. J. Tena, A. Eufrasio, J. Marques, F. Ferreira, T. Freitas, F. Carneiro, J. L. Goméz-Skarmeta, J. Bessa
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group

FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation

Auteurs: Sara Vaz, Fábio J. Ferreira, Joana C. Macedo, Gil Leor, Uri Ben-David, José Bessa, Elsa Logarinho
Publié dans: Cell Death & Disease, 2021, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-021-03822-5

Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Auteurs: Mariana C. Silva, Ângela Fernandes, Maria Oliveira, Carlos Resende, Alexandra Correia, Julio C. de-Freitas-Junior, Aonghus Lavelle, Jéssica Andrade-da-Costa, Magdalena Leander, Helena Xavier-Ferreira, José Bessa, Carina Pereira, Rui M. Henrique, Fátima Carneiro, Mário Dinis-Ribeiro, Ricardo Marcos-Pinto, Margarida Lima, Bernd Lepenies, Harry Sokol, José C. Machado, Manuel Vilanova, Salomé S
Publié dans: Cancer Immunology Research, Numéro 8/11, 2020, Page(s) 1407-1425, ISSN 2326-6066
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-20-0264

A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates

Auteurs: João Pedro Amorim, Ana Gali-Macedo, Hugo Marcelino, Renata Bordeira-Carriço, Silvia Naranjo, Solangel Rivero-Gil, Joana Teixeira, Mafalda Galhardo, Joana Marques, José Bessa
Publié dans: Cell Reports, Numéro 32/1, 2020, Page(s) 107862, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.107862

foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis

Auteurs: Fábio J Ferreira; Leonor Carvalho; Leonor Carvalho; Leonor Carvalho; Elsa Logarinho; Elsa Logarinho; José Bessa; José Bessa
Publié dans: Cells, Numéro 1, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10051241

Antisense Transcription across Nucleotide Repeat Expansions in Neurodegenerative and Neuromuscular Diseases: Progress and Mysteries

Auteurs: Ana F. Castro, Joana R. Loureiro, José Bessa, Isabel Silveira
Publié dans: Genes, Numéro 11/12, 2020, Page(s) 1418, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11121418

In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes–Associated Single Nucleotide Polymorphisms

Auteurs: Ana Eufrásio, Chiara Perrod, Fábio J. Ferreira, Marta Duque, Mafalda Galhardo, José Bessa
Publié dans: Diabetes, Numéro 69/12, 2020, Page(s) 2794-2805, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db19-1049

Ptf1a function and transcriptional cis-regulation, a cornerstone in vertebrate pancreas development.

Auteurs: Marta Duque; Marta Duque; João Amorim; João Amorim; José Bessa; José Bessa
Publié dans: FEBS, Numéro 1, 2021, ISSN 1742-464X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/febs.16075

CRISPR-Cas9-Mediated Genomic Deletions Protocol in Zebrafish

Auteurs: João Pedro Amorim, Renata Bordeira-Carriço, Ana Gali-Macedo, Chiara Perrod, José Bessa
Publié dans: STAR Protocols, Numéro 1/3, 2020, Page(s) 100208, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2020.100208

Intratumoral VEGF nanotrapper reduces gliobastoma vascularization and tumor cell mass

Auteurs: Flávia Sousa; Ana Isabel Costa-Pereira; Andrea Cruz; Fábio J Ferreira; Marcos Gouveia; José Bessa; Bruno Sarmento; Rui D. M. Travasso; I Pinto
Publié dans: Journal of Controlled Release, Numéro 1, 2021, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2021.09.031

Study of human regulatory mutations associated with pancreatic diseases by humanizing the zebrafish genome.

Auteurs: Inês Maria Batista da Costa
Publié dans: University of Oporto, Numéro 1, 2019
Éditeur: Universidade do Porto

Crispr-cas9 mutagenesis of the zebrafish foxm1

Auteurs: Carvalho, Leonor
Publié dans: University of Lisbon, 2018
Éditeur: Universidade de Lisboa, Faculdade de Ciências

Uncovering transcriptional cisregulatory elements active in zebrafish adult exocrine pancreas

Auteurs: Diogo José Coutinho Ribeiro
Publié dans: University of Oporto, Numéro 1, 2018
Éditeur: Universidade do Porto

O potencial regulatório em cis de sequências não codificantes associadas a diabetes tipo 2

Auteurs: Eufrásio, Ana Catarina Macedo
Publié dans: University of Aveiro, Numéro 1, 2018
Éditeur: Universidade de Aveiro

Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers

Auteurs: R. Bordeira-Carriço ; J. Teixeira ; M. Duque ; M. Galhardo ; D. Ribeiro ; R. Dominguez-Acemel ; P. N. Firbas ; J. J. Tena ; A. Eufrasio; J. Marques ; F. Ferreira ; T. Freitas ; F. Carneiro ; J. L. Goméz-Skarmeta ; J. Bessa
Publié dans: Biorxvi, 2020
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/2020.04.27.064220

A master cis-regulatory element in the FOXM1/RHNO1/TEAD4 landscape drives cellular senescence

Auteurs: Fábio Júnio Ferreira, Joana Teixeira, Mafalda Galhardo, Elsa Logarinho, José Bessa
Publié dans: Genome Biology, 2022, ISSN 1474-760X
Éditeur: BioMed Central

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