Selecting genetic lesions with essential function for patients' leukaemia in vivo as targets for precision medicine

Publications

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Auteurs: Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias
Publié dans: Biomarker Research, Numéro 8/1, 2020, ISSN 2050-7771
Éditeur: BioMed Central, Springer Nature
DOI: 10.1186/s40364-020-00226-z

Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC specific T-cell bispecific antibody

Auteurs: Christian Augsberger, Gerulf Hänel, Wei Xu, Vesna Pulko, Lydia Jasmin Hanisch, Angelique Augustin, John Challier, Katharina Hunt, Binje Vick, Pier Edoardo Rovatti, Christina Krupka, Maurine Rothe, Anne Schönle, Johannes Sam, Emmanuelle Lezan, Axel Ducret, Daniela Ortiz-Franyuti, Antje-Christine Walz, Jörg Benz, Alexander Bujotzek, Felix S Lichtenegger, Christian Gassner, Alejandro Carpy, Victor
Publié dans: Blood, 2021, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020010477

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Auteurs: Basit Salik, Hangyu Yi, Nunki Hassan, Nancy Santiappillai, Binje Vick, Patrick Connerty, Alastair Duly, Toby Trahair, Andrew J. Woo, Dominik Beck, Tao Liu, Karsten Spiekermann, Irmela Jeremias, Jianlong Wang, Maria Kavallaris, Michelle Haber, Murray D. Norris, Dan A. Liebermann, Richard J. D'Andrea, Christopher Murriel, Jenny Y. Wang
Publié dans: Cancer Cell, Numéro 38/2, 2020, Page(s) 263-278.e6, ISSN 1535-6108
Éditeur: Cell Press
DOI: 10.1016/j.ccell.2020.05.014

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Auteurs: Eliza Yankova, Wesley Blackaby, Mark Albertella, Justyna Rak, Etienne De Braekeleer, Georgia Tsagkogeorga, Ewa S. Pilka, Demetrios Aspris, Dan Leggate, Alan G. Hendrick, Natalie A. Webster, Byron Andrews, Richard Fosbeary, Patrick Guest, Nerea Irigoyen, Maria Eleftheriou, Malgorzata Gozdecka, Joao M. L. Dias, Andrew J. Bannister, Binje Vick, Irmela Jeremias, George S. Vassiliou, Oliver Rausch, Kon
Publié dans: Nature, Numéro 593/7860, 2021, Page(s) 597-601, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-021-03536-w

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Auteurs: Ali Khateb, Anagha Deshpande, Yongmei Feng, Darren Finlay, Joo Sang Lee, Ikrame Lazar, Bertrand Fabre, Yan Li, Yu Fujita, Tongwu Zhang, Jun Yin, Ian Pass, Ido Livneh, Irmela Jeremias, Carol Burian, James R. Mason, Ronit Almog, Nurit Horesh, Yishai Ofran, Kevin Brown, Kristiina Vuori, Michael Jackson, Eytan Ruppin, Aniruddha J. Deshpande, Ze’ev A. Ronai
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25664-7

Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

Auteurs: Diego Sánchez‐Martínez, Francisco Gutiérrez‐Agüera, Paola Romecin, Meritxell Vinyoles, Marta Palomo, Néstor Tirado, Samanta Romina Zanetti, Manel Juan, Michela Carlet, Irmela Jeremias, Pablo Menéndez
Publié dans: Clinical and Translational Medicine, Numéro 11/2, 2021, ISSN 2001-1326
Éditeur: Wiley Online Library
DOI: 10.1002/ctm2.280

The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis

Auteurs: Volker C. Kirsch, Christina Orgler, Simone Braig, Irmela Jeremias, David Auerbach, Rolf Müller, Angelika M. Vollmar, Stephan A. Sieber
Publié dans: Angewandte Chemie International Edition, Numéro 59/4, 2020, Page(s) 1595-1600, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911158

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

Auteurs: Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallée, Sébastien Lemieux, Patrick Gendron, Christian Rohde, Jianglong Xia, Prarabdha Jagdhane, Carsten Müller-Tidow, Daniel B. Lipka, Suzan Imren, R. Keith Humphries, Claudia Waskow, Binje Vick, Irmela Jeremias, Guillaume Richard-Carpentier, Josée Hébert, Guy Sauvageau, Judith B. Zaugg, Frédéric Barabé, Car
Publié dans: Blood, Numéro 134/3, 2019, Page(s) 263-276, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2018862383

SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells

Auteurs: Siret Tahk, Binje Vick, Björn Hiller, Saskia Schmitt, Anetta Marcinek, Enrico D. Perini, Alexandra Leutbecher, Christian Augsberger, Anna Reischer, Benjamin Tast, Andreas Humpe, Irmela Jeremias, Marion Subklewe, Nadja C. Fenn, Karl-Peter Hopfner
Publié dans: Journal of Hematology & Oncology, Numéro 14/1, 2021, ISSN 1756-8722
Éditeur: BioMed Central
DOI: 10.1186/s13045-021-01163-6

TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition

Auteurs: Shiva Bamezai, Deniz Demir, Alex Jose Pulikkottil, Fabio Ciccarone, Elena Fischbein, Amit Sinha, Chiara Borga, Geertruy te Kronnie, Lüder-Hinrich Meyer, Fabian Mohr, Maria Götze, Paola Caiafa, Klaus-Michael Debatin, Konstanze Döhner, Hartmut Döhner, Irene González-Menéndez, Leticia Quintanilla-Fend, Tobias Herold, Irmela Jeremias, Michaela Feuring-Buske, Christian Buske, Vijay P. S. Rawat
Publié dans: Leukemia, Numéro 35/2, 2021, Page(s) 389-403, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/s41375-020-0864-3

Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice

Auteurs: Sarah Ebinger, Christina Zeller, Michela Carlet, Daniela Senft, Johannes W. Bagnoli, Wen-Hsin Liu, Maja Rothenberg-Thurley, Wolfgang Enard, Klaus H. Metzeler, Tobias Herold, Karsten Spiekermann, Binje Vick, Irmela Jeremias
Publié dans: Haematologica, Numéro 105/12, 2020, Page(s) 2855-2860, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.226282

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

Auteurs: Sarah Ebinger, Erbey Ziya Özdemir, Christoph Ziegenhain, Sebastian Tiedt, Catarina Castro Alves, Michaela Grunert, Michael Dworzak, Christoph Lutz, Virginia A. Turati, Tariq Enver, Hans-Peter Horny, Karl Sotlar, Swati Parekh, Karsten Spiekermann, Wolfgang Hiddemann, Aloys Schepers, Bernhard Polzer, Stefan Kirsch, Martin Hoffmann, Bettina Knapp, Jan Hasenauer, Heike Pfeifer, Renate Panzer-Grümaye
Publié dans: Cancer Cell, Numéro 30/6, 2016, Page(s) 849-862, ISSN 1535-6108
Éditeur: Cell Press
DOI: 10.1016/j.ccell.2016.11.002

The target landscape of clinical kinase drugs

Auteurs: Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne
Publié dans: Science, Numéro 358/6367, 2017, Page(s) eaan4368, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aan4368

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Auteurs: Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. B
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-07620-0

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

Auteurs: K Reiter, H Polzer, C Krupka, A Maiser, B Vick, M Rothenberg-Thurley, K H Metzeler, D Dörfel, H R Salih, G Jung, E Nößner, I Jeremias, W Hiddemann, H Leonhardt, K Spiekermann, M Subklewe, P A Greif
Publié dans: Leukemia, Numéro 32/2, 2017, Page(s) 313-322, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2017.257

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

Auteurs: Stefanie Göllner, Thomas Oellerich, Shuchi Agrawal-Singh, Tino Schenk, Hans-Ulrich Klein, Christian Rohde, Caroline Pabst, Tim Sauer, Mads Lerdrup, Sigal Tavor, Friedrich Stölzel, Sylvia Herold, Gerhard Ehninger, Gabriele Köhler, Kuan-Ting Pan, Henning Urlaub, Hubert Serve, Martin Dugas, Karsten Spiekermann, Binje Vick, Irmela Jeremias, Wolfgang E Berdel, Klaus Hansen, Arthur Zelent, Claudia Wi
Publié dans: Nature Medicine, Numéro 23/1, 2017, Page(s) 69-78, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/nm.4247

CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC

Auteurs: I Tirado-Gonzalez, E Czlonka, A Nevmerzhitskaya, D Soetopo, E Bergonzani, A Mahmoud, A Contreras, I Jeremias, U Platzbecker, J P Bourquin, U Kloz, F Van der Hoeven, H Medyouf
Publié dans: Leukemia, Numéro 32/4, 2017, Page(s) 1049-1052, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2017.346

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice

Auteurs: Birgitta Christine Heckl, Michela Carlet, Binje Vick, Catrin Roolf, Ameera Alsadeq, Michaela Grunert, Wen-Hsin Liu, Andrea Liebl, Wolfgang Hiddemann, Rolf Marschalek, Denis Martin Schewe, Karsten Spiekermann, Christian Junghanss, Irmela Jeremias
Publié dans: Leukemia & Lymphoma, 2018, Page(s) 1-4, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.1080/10428194.2018.1509314

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

Auteurs: Jennifer R. Lynch, Basit Salik, Patrick Connerty, Binje Vick, Halina Leung, Aster Pijning, Irmela Jeremias, Karsten Spiekermann, Toby Trahair, Tao Liu, Michelle Haber, Murray D. Norris, Andrew J. Woo, Philip Hogg, Jianlong Wang, Jenny Y. Wang
Publié dans: Leukemia, 2019, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/s41375-018-0354-z

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in <i>FLT3</i>-ITD AML with concurrent epigenetic mutations

Auteurs: Anne-Kathrin Garz, Saskia Wolf, Sonja Grath, Verena Gaidzik, Stefan Habringer, Binje Vick, Martina Rudelius, Christoph Ziegenhain, Sylvia Herold, Marie-Theresa Weickert, Martha Smets, Christian Peschel, Robert A.J. Oostendorp, Sebastian Bultmann, Irmela Jeremias, Christian Thiede, Konstanze Döhner, Ulrich Keller, Katharina S. Götze
Publié dans: Oncotarget, Numéro 8/65, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.21877

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics

Auteurs: Stefan Habringer, Constantin Lapa, Peter Herhaus, Margret Schottelius, Rouzanna Istvanffy, Katja Steiger, Julia Slotta-Huspenina, Andreas Schirbel, Heribert Hänscheid, Stefan Kircher, Andreas K. Buck, Katharina Götze, Binje Vick, Irmela Jeremias, Markus Schwaiger, Christian Peschel, Robert Oostendorp, Hans-Jürgen Wester, Götz-Ulrich Grigoleit, Ulrich Keller
Publié dans: Theranostics, Numéro 8/2, 2018, Page(s) 369-383, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.21397

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL

Auteurs: Ina-Katrin Siekmann, Kevin Dierck, Sebastian Prall, Marianne Klokow, Julia Strauss, Sophia Buhs, Antonina Wrzeszcz, Michael Bockmayr, Florian Beck, Magdalena Trochimiuk, Kristina Gottschling, Victoria Martens, Melissa Khosh-Naucke, Helwe Gerull, Jürgen Müller, Lena Behrmann, Martin Blohm, René P. Zahedi, Irmela Jeremias, Albert Sickmann, Peter Nollau, Martin A. Horstmann
Publié dans: Blood Advances, Numéro 2/19, 2018, Page(s) 2554-2567, ISSN 2473-9529
Éditeur: Blood Journal
DOI: 10.1182/bloodadvances.2018020693

Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

Auteurs: Sannia Sarrach, Yuanchi Huang, Sebastian Niedermeyer, Matthias Hachmeister, Laura Fischer, Sebastian Gille, Min Pan, Brigitte Mack, Gisela Kranz, Darko Libl, Juliane Merl-Pham, Stefanie M. Hauck, Elisa Paoluzzi Tomada, Matthias Kieslinger, Irmela Jeremias, Antonio Scialdone, Olivier Gires
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-20131-8

A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia

Auteurs: Daniela Senft, Irmela Jeremias
Publié dans: Experimental Hematology, Numéro 69, 2019, Page(s) 1-10, ISSN 0301-472X
Éditeur: Elsevier BV
DOI: 10.1016/j.exphem.2018.09.006

Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics

Auteurs: Fabian Koczian, Olga Nagło, Jan Vomacka, Binje Vick, Phil Servatius, Themistoklis Zisis, Britta Hettich, Uli Kazmaier, Stephan A. Sieber, Irmela Jeremias, Stefan Zahler, Simone Braig
Publié dans: Haematologica, Numéro 104/3, 2019, Page(s) 546-555, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.197368

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Auteurs: Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25963-z

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Auteurs: Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory, Dorothee Winterberg, Antony Cousins, Michaela Vossen-Gajcy, Olta Ibruli, Christian Vokuhl, Gunnar Cario, Omar El Ayoubi, Lisa Kramer, Matthias Ritgen, Monika Brüggemann, Robert Häsler, Martin Schrappe, Stephan Fuhrmann, Christina Halsey, Irmela Jeremias, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq & Denis M. Schewe
Publié dans: communications biology, 2021, ISSN 2399-3642
Éditeur: Springer Nature
DOI: 10.1038/s42003-020-01591-z

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body

Auteurs: Chenchen Pan, Oliver Schoppe, Arnaldo Parra-Damas, Ruiyao Cai, Mihail Ivilinov Todorov, Gabor Gondi, Bettina von Neubeck, Nuray Böğürcü-Seidel, Sascha Seidel, Katia Sleiman, Christian Veltkamp, Benjamin Förstera, Hongcheng Mai, Zhouyi Rong, Omelyan Trompak, Alireza Ghasemigharagoz, Madita Alice Reimer, Angel M. Cuesta, Javier Coronel, Irmela Jeremias, Dieter Saur, Amparo Acker-Palmer, Till Ac
Publié dans: Cell, Numéro 179/7, 2019, Page(s) 1661-1676.e19, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2019.11.013

CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries

Auteurs: Martin Becker, Heidi Noll-Puchta, Diana Amend, Florian Nolte, Christiane Fuchs, Irmela Jeremias, Christian J Braun
Publié dans: Nucleic Acids Research, 2020, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa459

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Auteurs: A. Moretti, L. Fonteyne, F. Giesert, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, T. Fröhlich, F. Abdel Rahman, T. Haufe, S. Sun, V. Jurisch, B. Kessler, R. Hinkel, R. Dirschinger, E. Martens, C. Jilek, A. Graf, S. Krebs, G. Santamaria, M. Kurome, V. Zakhartchenko, B. Campbell, K. Voelse, A. Wolf, T. Ziegler, S. Reichert, S. Lee, F. Flenkenthaler, T. Do
Publié dans: Nature Medicine, Numéro 26/2, 2020, Page(s) 207-214, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-019-0738-2

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

Auteurs: Matteo Libero Baroni, Diego Sanchez Martinez, Francisco Gutierrez Aguera, Heleia Roca Ho, Maria Castella, Samanta Zanetti, Talia Velasco Hernandez, Rafael Diaz de la Guardia, Julio Castaño, Eduardo Anguita, Susana Vives, Josep Nomdedeu, Helene Lapillone, Anne E Bras, Vincent H J van der Velden, Jordi Junca, Pedro Marin, Alex Bataller, Jordi Esteve, Binje Vick, Irmela Jeremias, Angel Lopez, Marc S
Publié dans: Journal for ImmunoTherapy of Cancer, Numéro 8/1, 2019, Page(s) e000845, ISSN 2051-1426
Éditeur: BMJ Journals
DOI: 10.1136/jitc-2020-000845

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Auteurs: Bo-Rui Chen, Anagha Deshpande, Karina Barbosa, Maria Kleppe, Xue Lei, Narayana Yeddula, Pablo Sánchez Vela, Alexandre Rosa Campos, Robert J. Wechsler-Reya, Anindya Bagchi, Soheil Meshinchi, Connie Eaves, Irmela Jeremias, Torsten Haferlach, David A. Frank, Ze’ev Ronai, Sumit Chanda, Scott A. Armstrong, Peter D. Adams, Ross L. Levine, Aniruddha J. Deshpande
Publié dans: Blood, Numéro 137/24, 2021, Page(s) 3403-3415, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020009023

A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

Auteurs: Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-91760-9

Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR

Auteurs: Dana Stenger, Tanja A. Stief, Theresa Kaeuferle, Semjon Willier, Felicitas Rataj, Kilian Schober, Binje Vick, Ramin Lotfi, Beate Wagner, Thomas G. P. Grünewald, Sebastian Kobold, Dirk H. Busch, Irmela Jeremias, Franziska Blaeschke, Tobias Feuchtinger
Publié dans: Blood, Numéro 136/12, 2020, Page(s) 1407-1418, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood.2020005185

Requirement for LIM kinases in acute myeloid leukemia

Auteurs: Patrizia Jensen, Michela Carlet, Richard F. Schlenk, Andrea Weber, Jana Kress, Ines Brunner, Mikołaj Słabicki, Gregor Grill, Simon Weisemann, Ya-Yun Cheng, Irmela Jeremias, Claudia Scholl, Stefan Fröhling
Publié dans: Leukemia, Numéro 34/12, 2020, Page(s) 3173-3185, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/s41375-020-0943-5

X-Linked inhibitor of apoptosis protein (XIAP) exhibits an essential role of patients' acute lymphoblastic leukemia cells growing in vivo

Auteurs: J. Vergalli, M. Carlet, T. Hoffmann, M. Roth, J. Zuber, I. Jeremias
Publié dans: European Journal of Cancer, Numéro 69, 2016, Page(s) S58-S59, ISSN 0959-8049
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/s0959-8049(16)32762-9

Single Cell Clones Derived from a Patient's AML Xenograft Display Genetic and Functional Heterogeneity

Auteurs: Christina Maria Zeller, Daniel Richter, Binje Vick, Tobias Herold, Johannes Bagnoli, Maja Rothenberg-Thurley, Klaus H. Metzeler, Karsten Spiekermann, Wolfgang Enard, Irmela Jeremias
Publié dans: Blood, Numéro 134/Supplement_1, 2019, Page(s) 1450-1450, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2019-127867

A CRISPR/Cas9 Library Screen in Patients' Leukemia Cells In Vivo

Auteurs: Ehsan Bahrami, Martin Becker, Anna-Katharina Wirth, Jan Phillip Schmid, Tobias Herold, Rupert Öllinger, Roland Rad, Irmela Jeremias
Publié dans: Blood, Numéro 134/Supplement_1, 2019, Page(s) 3945-3945, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2019-124288

Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia

Auteurs: Irmela Jeremias, Denis M. Schewe
Publié dans: Biological Mechanisms of Minimal Residual Disease and Systemic Cancer, Numéro 1100, 2018, Page(s) 127-139, ISBN 978-3-319-97745-4
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-319-97746-1_8

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