Objective Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population inEurope and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement therapies(CTs) are considered very promising, in particular with the advent of stem-cell reprogramming technologies. However, afundamental challenge in the medical application of CTs in the brain of patients lies in the lack of control of cell behaviour atthe site of transplantation, and particularly their differentiation and oriented growth. The aim of this project is to introduce afundamentally new concept for remote control of cellular functions by means of magnetic manipulation. The technology isbased on magnetic nanoparticles functionalized with proteins involved in cellular signalling cascades. Thesebiofunctionalized MNPs (bMNPs) will be delivered into target cells, where they act as intracellular signalling platformsactivatable in a spatially and temporally controlled manner by external magnetic fields. The project will focus on engineeringthese tools for the control of neuronal cell programming and fibre outgrowth by hijacking Wnt and neurotrophin signalling,respectively, with the ulti-mate objective of advancing cell replacement therapies for PD using dopaminergic precursorneurons.To achieve this ambitious goal, we have gathered an interdisciplinary consortium interfacing scientists having cutting-edgeknow-how in bMNP engineering, surface functionalization and cellular nanobiophysics with renowned experts in neuronalcell differentiation, stem-cell reprogramming and regenerative (nano-)medicine. By exploiting this complementary expertise,a novel, versatile technology for magnetic control of intracellular signalling is envis-aged, which will be a breakthrough forremote actuation of cellular functions and its successful implementation in CTs for neurodegenerative diseases and injurieswithin the following decade. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencescell biologycell signalingmedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologynanotechnologynano-materialsmedical and health sciencesbasic medicineneurologyparkinson Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Call for proposal H2020-FETOPEN-2014-2015 See other projects for this call Sub call H2020-FETOPEN-2014-2015-RIA Funding Scheme RIA - Research and Innovation action Coordinator INSTITUT CURIE Net EU contribution € 638 750,00 Address RUE D ULM 26 75231 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 638 750,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 403 280,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 488 276,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. SORBONNE UNIVERSITE France Net EU contribution € 84 996,00 Address 21 RUE DE L'ECOLE DE MEDECINE 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 84 996,00 UNIVERSITY OF KEELE ROYAL CHARTER United Kingdom Net EU contribution € 808 281,71 Address KEELE UNIVERSITY FINANCE DPT ST5 5BG Keele See on map Region West Midlands (England) Shropshire and Staffordshire Staffordshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 808 281,71 UNIVERSITAET OSNABRUECK Germany Net EU contribution € 654 000,00 Address NEUER GRABEN/SCHLOSS 29 49074 Osnabrueck See on map Region Niedersachsen Weser-Ems Osnabrück, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 654 000,00 RUHR-UNIVERSITAET BOCHUM Germany Net EU contribution € 681 875,00 Address UNIVERSITAETSSTRASSE 150 44801 Bochum See on map Region Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 681 875,00 EFFICIENT INNOVATION SAS France Net EU contribution € 150 000,00 Address AVENUE CLEMENT ADER 55 34170 CASTELNAU LE LEZ See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 150 000,00 THE UNIVERSITY OF BIRMINGHAM United Kingdom Net EU contribution € 51 843,29 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 51 843,29