Role of autonomous B cell receptor signalling and external antigen in the pathogenesis of chronic lymphocytic leukaemia (CLL)

Informations projet

Autonomous CLL-BCRs

N° de convention de subvention: 694992

DOI 10.3030/694992

Projet clôturé

Date de signature de la CE 20 Juin 2016

Date de début 1 Novembre 2016

Date de fin 31 Octobre 2021

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total € 2 256 250,00

Contribution de l’UE € 2 256 250,00

Coordonné par

UNIVERSITAET ULM
Germany

Publications

Peer reviewed articles (15)

The determinants of B cell receptor signaling as prototype molecular biomarkers of leukemia

Auteurs: Antonella Nicolò, Alexandra T. Linder, Hassan Jumaa and Palash C. Maity
Publié dans: Frontiers in Oncology, 2021, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.771669

B-cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia

Auteurs: Andrea N Mazzarello, Eva Gentner-Göbel, Marcus Dühren-von Minden, Tatyana N Tarasenko, Antonella Nicolò, Gerardo Ferrer, Stefano Vergani, Yun Liu, Davide Bagnara, Kanti R Rai, Jan A Burger, Peter J McGuire, Palash C Maity, Hassan Jumaa, Nicholas Chiorazzi
Publié dans: Journal of Clinical Investigation, 2021, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci149308

Primary Immune Responses and Affinity Maturation Are Controlled by IgD

Auteurs: Timm Amendt, Omar El Ayoubi, Alexandra T. Linder, Gabriele Allies, Marc Young, Corinna S. Setz, Hassan Jumaa
Publié dans: Frontiers in Immunology, Numéro 12, 2021, ISSN 1664-3224
Éditeur: Frontiers of Immunology
DOI: 10.3389/fimmu.2021.709240

Defective Allelic Exclusion by IgD in the Absence of Autoantigen

Auteurs: Valerio Renna, Elena Surova, Ahmad Khadour, Moumita Datta, Timm Amendt, Elias Hobeika and Hassan Jumaa
Publié dans: The Journal of Immunology, 2021, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.2100726

PI3K induces B-cell development and regulates B cell identity

Auteurs: Hend Abdelrasoul, Markus Werner, Corinna S. Setz, Klaus Okkenhaug, Hassan Jumaa
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-19460-5

Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor

Auteurs: Joseena Iype, Moumita Datta, Ahmad Khadour, Rudolf Übelhart, Antonella Nicolò, Tim Rollenske, Marcus Dühren-von Minden, Hedda Wardemann, Palash C. Maity, Hassan Jumaa
Publié dans: The Journal of Immunology, Numéro 202/5, 2019, Page(s) 1417-1427, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1800690

Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4

Auteurs: Palash C. Maity, Moumita Datta, Antonella Nicolò, Hassan Jumaa
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.02988

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Auteurs: Ameera Alsadeq, Lennart Lenk, Anila Vadakumchery, Antony Cousins, Christian Vokuhl, Ahmad Khadour, Fotini Vogiatzi, Felix Seyfried, Lueder-Hinrich Meyer, Gunnar Cario, Elias Hobeika, Klaus-Michael Debatin, Christina Halsey, Martin Schrappe, Denis M. Schewe, Hassan Jumaa
Publié dans: Blood, Numéro 132/15, 2018, Page(s) 1614-1617, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2018-04-844209

PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis

Auteurs: Corinna S. Setz, Eva Hug, Ahmad Khadour, Hend Abdelrasoul, Mayas Bilal, Elias Hobeika, Hassan Jumaa
Publié dans: Cell Reports, Numéro 24/2, 2018, Page(s) 391-405, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.06.035

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Auteurs: Katharina Imkeller, Stephen W. Scally, Alexandre Bosch, Gemma Pidelaserra Martí, Giulia Costa, Gianna Triller, Rajagopal Murugan, Valerio Renna, Hassan Jumaa, Peter G. Kremsner, B. Kim Lee Sim, Stephen L. Hoffman, Benjamin Mordmüller, Elena A. Levashina, Jean-Philippe Julien, Hedda Wardemann
Publié dans: Science, Numéro 360/6395, 2018, Page(s) 1358-1362, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aar5304

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

Auteurs: Gang Xiao, Lai N. Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M. Weinstock, Thomas G. Graeber, Markus Müschen
Publié dans: Cell, Numéro 173/2, 2018, Page(s) 470-484.e18, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2018.02.048

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Auteurs: Claudia Minici, Maria Gounari, Rudolf Übelhart, Lydia Scarfò, Marcus Dühren-von Minden, Dunja Schneider, Alpaslan Tasdogan, Alabbas Alkhatib, Andreas Agathangelidis, Stavroula Ntoufa, Nicholas Chiorazzi, Hassan Jumaa, Kostas Stamatopoulos, Paolo Ghia, Massimo Degano
Publié dans: Nature Communications, Numéro 8, 2017, Page(s) 15746, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms15746

Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR

Auteurs: Corinna S Setz, Ahmad Khadour, Valerio Renna, Joseena Iype, Eva Gentner, Xiaocui He, Moumita Datta, Marc Young, Lars Nitschke, Jürgen Wienands, Palash C Maity, Michael Reth, Hassan Jumaa
Publié dans: The EMBO Journal, 2019, Page(s) e100249, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.2018100249

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Auteurs: Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-16927-w

IGLV3-21 * 01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Auteurs: Palash C. Maity, Mayas Bilal, Marvyn T. Koning, Marc Young, Cornelis A. M. van Bergen, Valerio Renna, Antonella Nicolò, Moumita Datta, Eva Gentner-Göbel, Rob S. Barendse, Sebastiaan F. Somers, Ruben A. L. de Groen, Joost S. P. Vermaat, Daniela Steinbrecher, Christof Schneider, Eugen Tausch, Tamara Bittolo, Riccardo Bomben, Andrea Nicola Mazzarello, Giovanni del Poeta, Wilma G. M. Kroes, J. Tom v
Publié dans: Proceedings of the National Academy of Sciences, Numéro 117/8, 2020, Page(s) 4320-4327, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1913810117