Repair of Junctional Atrioventricular Conduction and Impulse Formation

Project Information

REJUVENATION

Grant agreement ID: 714866

DOI 10.3030/714866

Project closed

EC signature date 13 February 2017

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 995,00

EU contribution € 1 499 995,00

Coordinated by

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

Publications

Peer reviewed articles (9)

A single cell transcriptional roadmap of human pacemaker cell differentiation

Author(s): Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arie O Verkerk, Vincent M Christoffels, Gerard JJ Boink, Harsha D Devalla
Published in: eLife, Issue 2050084X, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.76781

Transcriptional regulation of the cardiac conduction system

Author(s): Vincent W. W. van Eif, Harsha D. Devalla, Gerard J. J. Boink, Vincent M. Christoffels
Published in: Nature Reviews Cardiology, 2018, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-018-0031-y

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System

Author(s): Saritha Adepu, Erik Oosterwerff, Vincent Christoffels, Gerard Boink
Published in: Medicines, Issue 5/2, 2018, Page(s) 48, ISSN 2305-6320
Publisher: MDPI
DOI: 10.3390/medicines5020048

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

Author(s): Mohan RA, Mommersteeg MTM, Domínguez JN, Choquet C, Wakker V, de Gier-de Vries C, Boink GJJ, Boukens BJ, Miquerol L, Verkerk AO, Christoffels VM
Published in: Development, 2018, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.167361

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

Author(s): Végh AMD, den Haan AD, Cócera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ
Published in: Molecules, 2019, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24010181

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

Author(s): Rajiv A. Mohan, Fernanda M. Bosada, Jan H. van Weerd, Karel van Duijvenboden, Jianan Wang, Mathilda T. M. Mommersteeg, Ingeborg B. Hooijkaas, Vincent Wakker, Corrie de Gier-de Vries, Ruben Coronel, Gerard J. J. Boink, Jeroen Bakkers, Phil Barnett, Bas J. Boukens, Vincent M. Christoffels
Published in: Proceedings of the National Academy of Sciences, Issue 117/31, 2020, Page(s) 18617-18626, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1919379117

Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells

Author(s): Alexandra Wiesinger, Gerard J.J. Boink, Vincent M. Christoffels, Harsha D. Devalla
Published in: Stem Cell Reports, Issue 16/11, 2021, Page(s) 2589-2606, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2021.09.010

Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1

Author(s): Anna M. D. Végh, Arie O. Verkerk, Lucía Cócera Ortega, Jianan Wang, Dirk Geerts, Mischa Klerk, Kirsten Lodder, Ruby Nobel, Anke J. Tijsen, Harsha D. Devalla, Vincent M. Christoffels, Max Medina-Ramírez, Anke M. Smits, Hanno L. Tan, Ronald Wilders, Marie José T. H. Goumans, Gerard J. J. Boink
Published in: Frontiers in Physiology, Issue 11, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.588679

Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models

Author(s): Jiuru Li, Alexandra Wiesinger, Lianne Fokkert, Bastiaan J. Boukens, Arie O. Verkerk, Vincent M. Christoffels, Gerard J.J. Boink, Harsha D. Devalla
Published in: Journal of Tissue Engineering, Issue 20417314, 2022, ISSN 2041-7314
Publisher: SAGE journals
DOI: 10.1177/20417314221127908