circular RNA Biology Training Network: from biogenesis to biomarkers

Project Information

circRTrain

Grant agreement ID: 721890

DOI 10.3030/721890

Project closed

EC signature date 31 August 2016

Start date 1 January 2017

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 865 078,52

EU contribution € 3 865 078,52

Coordinated by

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany

Deliverables

Other (3)

Organization, execution and evaluation of training events completed

Organization execution and evaluation of training events completed

ESR'S thesis submitted

ESRS thesis submitted

Recruitment of 15 ESRs

Documents, reports (2)

Full set of event reports and publication list
Dissemination Toolkit

Websites, patent fillings, videos etc. (1)

Project Website

Publications

Peer reviewed articles (19)

Widespread occurrence of circular RNA in eukaryotes

Author(s): Irene Bozzoni
Published in: Nature Reviews Genetics, Issue 22/9, 2021, Page(s) 550-551, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-021-00375-3

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

Author(s): Lotte Victoria Winther Stagsted, Eoghan Thomas O'Leary, Karoline Kragh Ebbesen, Thomas Birkballe Hansen
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63088

Linking the association between circRNAs and Alzheimer’s disease progression by multi-tissue circular RNA characterization

Author(s): IJu Lo, Jamie Hill, Bjarni J. Vilhjálmsson, Jørgen Kjems
Published in: RNA Biology, Issue 17/12, 2020, Page(s) 1789-1797, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2020.1783487

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Author(s): Liviu-Ionut Moldovan, Thomas Birkballe Hansen, Morten Trillingsgaard Venø, Trine Line Hauge Okholm, Thomas Levin Andersen, Henrik Hager, Lars Iversen, Jørgen Kjems, Claus Johansen, Lasse Sommer Kristensen
Published in: BMC Medical Genomics, Issue 12/1, 2019, Page(s) 1-17, ISSN 1755-8794
Publisher: BioMed Central
DOI: 10.1186/s12920-019-0616-2

Past, present, and future of circ RNA s

Author(s): Ines Lucia Patop, Stas Wüst, Sebastian Kadener
Published in: The EMBO Journal, Issue 38/16, 2019, Page(s) 1-13, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100836

Long non‐coding RNAs in motor neuron development and disease

Author(s): Vamshidhar R. Vangoor, Andreia Gomes‐Duarte, R. Jeroen Pasterkamp
Published in: Journal of Neurochemistry, Issue 156/6, 2021, Page(s) 777-801, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15198

Circular RNAs in cell differentiation and development

Author(s): Gaia Di Timoteo, Francesca Rossi, Irene Bozzoni
Published in: Development, Issue 147/16, 2020, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.182725

An in vivo strategy for knockdown of circular RNAs

Author(s): Nagarjuna Reddy Pamudurti, Ines Lucia Patop, Aishwarya Krishnamoorthy, Reut Ashwal-Fluss, Osnat Bartok, Sebastian Kadener
Published in: Cell Discovery, Issue 6/1, 2020, Page(s) 11;6:52, ISSN 2056-5968
Publisher: Springer Nature
DOI: 10.1038/s41421-020-0182-y

A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma

Author(s): Kunal Das Mahapatra, Lorenzo Pasquali, Jonas Nørskov Søndergaard, Jan Lapins, István Balazs Nemeth, Eszter Baltás, Lajos Kemény, Bernhard Homey, Liviu-Ionut Moldovan, Jørgen Kjems, Claudia Kutter, Enikö Sonkoly, Lasse Sommer Kristensen, Andor Pivarcsi
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 1-12, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-59660-6

Design and application of circular RNAs with protein-sponge function

Author(s): Silke Schreiner, Anna Didio, Lee-Hsueh Hung, Albrecht Bindereif
Published in: Nucleic Acids Research, Issue 48/21, 2020, Page(s) 12326-12335, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1085

Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease‐specific expression profiles

Author(s): Liviu I. Moldovan, Lam C. Tsoi, Uppala Ranjitha, Henrik Hager, Stephen Weidinger, Johann E. Gudjonsson, Jørgen Kjems, Lasse S. Kristensen
Published in: Experimental Dermatology, Issue 30/8, 2021, Page(s) 1187-1196, ISSN 0906-6705
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/exd.14227

Methods to study circRNA-protein interactions

Author(s): Corinna J. Ulshöfer, Christina Pfafenrot, Albrecht Bindereif, Tim Schneider
Published in: Methods, Issue Volume 195, 2021, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2021.04.014

Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development

Author(s): Sara Brignani, Divya D.A. Raj, Ewoud R.E. Schmidt, Özge Düdükcü, Youri Adolfs, Anna A. De Ruiter, Mateja Rybiczka-Tesulov, Marieke G. Verhagen, Christiaan van der Meer, Mark H. Broekhoven, Juan A. Moreno-Bravo, Laurens M. Grossouw, Emilie Dumontier, Jean-François Cloutier, Alain Chédotal, R. Jeroen Pasterkamp
Published in: Neuron, Issue 107/4, 2020, Page(s) 684-702.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.05.037

circRNAs in Cancer

Author(s): Ines Lucia Patop, Sebastian Kadener
Published in: Current Opinion in Genetics & Development, Issue 48, 2018, Page(s) 121-127, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2017.11.007

Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis

Author(s): Vera Zywitza, Aristotelis Misios, Lena Bunatyan, Thomas E. Willnow, Nikolaus Rajewsky
Published in: Cell Reports, Issue 25/9, 2018, Page(s) 2457-2469.e8, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.11.003

CircVAMP3: A circRNA with a Role in Alveolar Rhabdomyosarcoma Cell Cycle Progression

Author(s): Francesca Rossi, Alvaro Centrón-Broco, Dario Dattilo, Gaia Di Timoteo, Marco Guarnacci, Alessio Colantoni, Manuel Beltran Nebot, Irene Bozzoni
Published in: Genes, Issue 12/7, 2021, Page(s) 985, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12070985

Modulation of circRNA Metabolism by m6A Modification

Author(s): Gaia Di Timoteo, Dario Dattilo, Alvaro Centrón-Broco, Alessio Colantoni, Marco Guarnacci, Francesca Rossi, Danny Incarnato, Salvatore Oliviero, Alessandro Fatica, Mariangela Morlando, Irene Bozzoni
Published in: Cell Reports, Issue 31/6, 2020, Page(s) 107641, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107641

Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS

Author(s): Eleonora D’Ambra, Tiziana Santini, Erika Vitiello, Sara D’Uva, Valentina Silenzi, Mariangela Morlando, Irene Bozzoni
Published in: iScience, 2021, Page(s) 103504, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2021.103504

Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy

Author(s): Andreia Gomes-Duarte, Sebastian Bauer, Morten T. Venø, Braxton A. Norwood, David C. Henshall, Jørgen Kjems, Felix Rosenow, Vamshidhar R. Vangoor, R. Jeroen Pasterkamp
Published in: Frontiers in Genetics, Issue 12, 2021, Page(s) 1-20, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2021.627907